L. G. Gegenava

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The oxidative stress-induced changes and feasibility of prevention of these changes with an aid of vitamines E and C were investigated in cultured brain cortex of the newborn albino rats. Modeling the oxidative stress was achieved with addition of H(2)O(2) into the nutrient medium. In order to prevent an oxidative stress-induced cytotoxic effect,(More)
Disorders of neurogenesis of cortical and subcortical structures in rat brain limbic system were studied in the offspring of rats that received ethanol during pregnancy. The methods used included the staining of histological sections with cresyl violet, in vitro culture, and electron paramagnetic resonance. Prenatal alcohol intoxication was shown to induce(More)
Testing in an elevated-type multiway labyrinth showed that adolescent rats (postnatal age, 30 days) make errors twice more rarely and reach the specified training criterion earlier than adult (60-day-old) animals. A relatively low emotional background and high research activity observed within the initial stage of the experiment accelerated the process of(More)
The aims of the present work were to measure neuron density in the limbic cortex in the offspring of female white rats given 15% ethanol solution during pregnancy and lactation and to address the possibility of correcting ethanol-induced impairments at the early stages of postnatal development (PND) using the antioxidant Dolivin. Neuron numbers were(More)
Toluene inhalation-induced intoxication (500 ррm) of albino mongrel rats within early stages of postnatal development (to postnatal day Р30) significantly suppressed realization of auriculonasocephalic reflex within the time interval preceding the period of beginning of visual perception, i.e., eye opening in young animals (Р7 to Р13). Later on (Р15 and(More)
Alterations of Na, K, Ca, and Mg concentration in the rat hippocampus were investigated with atomic-absorption method, in the process of learning and memory, following destruction of the medial septum and entorhinal cortex. These data were compared to those of the heavy metals, obtained in similar conditions. It was found that in learning and memory(More)
We studied variations in the concentration of Na, K, Ca, and Mg in the hippocampus of rats with damaged entorhinal cortex. The concentration of Mg, Na, K, and Ca remained practically unchanged, while the content of Zn and Cu increased during learning and memory retrieval in animals with damaged entorhinal cortex. Our results indicate that Zn and Cu,(More)
Neurogenesis was studied in the subcortical structures of the limbic system of the brain in the offspring of rats given ethanol during pregnancy. The following methods were used: examination of histological sections stained with cresyl violet, in vitro cultivation, and electron paramagnetic resonance. Prenatal intoxication with alcohol was found to induce(More)
To determine species-specific cells in mixed culture, obtained after simultaneous cultivation of dissociated cells of chick embryo midbrain tegmentum and newborn albino rat cerebral cortex, various DNA amounts were used for testing chick and rat cells. The study of cell structure of the aggregates revealed that in addition to the aggregates consisting of(More)
The number and weight of cells in the cortical and subcortical structures of the cerebral and cerebellar motor system in albino rats after a long-term exposure to toluene were determined. Toluene intoxication proved to kill projection neurons and interneurons in the sensorimotor cortex, ventrolateral thalamic nucleus, caudate nucleus, pallidum, red nucleus,(More)