L. G. Fuller

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We investigated two approaches for large-scale analysis and prediction of the spatial distribution of soil properties in an agricultural landscape in the Canadian prairies. The first approach was based on the implementation of nine types of digital terrain models (DTMs) and regression analysis of soil and topographic data. The second approach used a concept(More)
We show, for the first time, that the tumor suppressor PTEN can have tumor-promoting properties. We show that PTEN acquires these unexpected properties by enhancing gain-of-function mutant p53 (mut-p53) protein levels. We find that PTEN restoration to cells harboring mut-p53 leads to induction of G(1)-S cell cycle progression and cell proliferation and to(More)
The tyrosine kinase receptor c-Met and its ligand hepatocyte growth factor (HGF) are frequently overexpressed and the tumor suppressor PTEN is often mutated in glioblastoma. Because PTEN can interact with c-Met-dependent signaling, we studied the effects of PTEN on c-Met-induced malignancy and associated molecular events and assessed the potential(More)
Forest Managers in the UK and elsewhere are facing new threats such as climate change and novel pests and diseases. Strategies seek to coordinate and steer appropriate responses through raising awareness and encouraging action but little is known about how individual managers respond to disease threats. We studied how managers have responded to the threat(More)
Resilience is rapidly becoming a prominent concept in research, policy and practice. However, it is apparent that there is no consistent meaning of resilience being used by those involved in governing and managing forests and tree health. We aimed to (1) identify how the concept of resilience is defined in a range of decision-making contexts, (2) develop an(More)
Gap analysis is a tool that allows conservationists to quantify the effectiveness of protected areas at representing species diversity, but the lack of distribution maps for invertebrates has precluded its application to the world’s most diverse animal groups. Here, we overcome this limitation and conduct a gap analysis, using niche modelling, on the(More)
In Ireland only 2 % of the total land area is native woodland, which tends to be small and fragmented. Killarney National Park in south-west Ireland contains the most extensive semi-natural woodland in the country, and includes oak (Quercus petraea) and yew (Taxus baccata) woodlands which are internationally protected. Here, over-grazing by large(More)
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