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— Long-term hydrothermal generation planning (LTHTP) problems have been traditionally conceived as minimum cost-based optimization models. However, such policy may lead to unacceptable amounts of load curtailment in critical inflow scenarios, which are likely to be avoided. This paper describes a direct approach for the implementation of a Conditional(More)
Medullary thyroid carcinomas (MTC) occur sporadically or as part of inherited multiple endocrine neoplasia (MEN) type 2 syndromes. To recognize misdiagnosed familial cases and to establish the frequency of somatic mutations, a series of 50 patients, clinically diagnosed with sporadic MTC, were analyzed for mutations in the RET proto-oncogene. The clinical(More)
BACKGROUND Secretory phospholipase A2 (sPLA2) plays a pivotal role in acute respiratory distress syndrome (ARDS). This enzyme seems an interesting target to reduce surfactant catabolism and lung tissue inflammation. Varespladib is a specifically designed indolic sPLA2 inhibitor, which has shown promising results in animals and adults. No specific data in(More)
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