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The authors discuss the historical aspects, as well as the various etiological and clinical factors which contribute to the so-called pharmacogenically induced depressions during treatment by means of neuroleptics generally, and long-term neuroleptics especially. An open study on 161 schizophrenic patients treated by means of fluspirilene and 123 patients(More)
In this double-blind study on 50 depressive patients viloxazine in dosages between 150-300 mg/die, showed to be a very active and well tolerated thymoleptic substance. Its profile of activity seems similar to that of imipramine. The differences in favour of viloxazine were: a more rapid onset of its effect, a more balanced stimulation of energetical level(More)
The clinical profile and side-effects of perphenazin-enanthate and fluspirilene were compared in 45 female chronic schizophrenic patients. 100 mg perphenazin-enanthate fortnightly or 8 mg fluspirilene weekly were administered. During the four months' period the psychopathological and somatic symptoms were evaluated by means of the AMP-system and the(More)
The authors discuss the character of lithium-induced tremor. Three various measuring methods are presented: an accelerometer, a hole-plate and an apparatus based on aimed tapping. A fourth apparatus is proposed. The first three methods were applied on 16 patients who received lithium therapy and on a control group consisting of 22 normal persons. The(More)
In a cross-over study with Pindolol, 15 mg/day, against placebo, we studied during 4 weeks 22 patients aged between 20 and 65 years who where treated by means of lithium carbonate retard (Quilonum Retard). The tremor was measured twice a week by means of three apparative methods: an accelerometer, a 'hole-plate' and an 'aimed tapping plate', both(More)
  • L Floru
  • 1977
This paper is an up-to-date review of the literature on the subject, as well as of own research. The paper discusses pharmacological and experimental data concerning the central nervous activity of beta-blocking agents. Their use in anxiolysis - in adults and children -, ethological research, their indications in the treatment of various psychoses,(More)