L. F. Kalenova

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Superinfection of animals having Opisthorchis invasion with Mycobacterium tuberculosis leads to destabilization of host-parasite relationships in opisthorchiasis and formation of new host-parasitocenotic interrelations whose manifestation depends on the phase of the invasive process. At the acute invasive phase of mixed pathology (2 weeks) the activity of(More)
The immunobiological potential of a new microorganism species isolated from permafrost specimens (PMO strain 3 M) collected from the Mammoth Mountain in Yakutia was studied in laboratory mice. PMO injected intraperitoneally in doses of 2500 to 50 × 106 microbial bodies caused characteristic dose-dependent effects on the structure and functions of the immune(More)
Local application of ointment with Bacillus spp. strain MG8 (15,000-20,000 living bacterial cells), isolated from permafrost specimens, on the skin wound of about 60 mm2 stimulated the reparation processes in experimental mice. A possible mechanism stimulating the regeneration of the damaged tissues under the effect of MG8 could be modulation of the immune(More)
Permafrost is widely distributed in the Northern Hemisphere, and its age reaches hundreds of thousands and millions of years. Permafrost contains alive microorganisms which are not frozen due to relatively high temperature of the environment (-2...-8 degrees C), but the microorganisms are immobilized and therefore aged probably similar to the age of(More)
Transient changes in environmental temperature produce a short-term, but significant effect on the immune system reactions in laboratory mice. Activities of nonspecific resistance factors (peritoneal macrophages) in mice exposed in warm or cold water were characterized by similar reactions, while the reactions of cellular and humoral immunity were opposite.(More)
Experiments on inbred animals showed that short-term exposure in cold water significantly modified structural and functional parameters of the immune system at different levels of its organization, from bone marrow hemopoiesis to effector stage of the immune response to antigen. The thermal factor caused changes in nonspecific and specific mechanisms of the(More)
Bacillus strain 3M isolated from samples of permafrost from Mamontova Mountain (Yakutiya) affected the quality and duration of life of “elderly” mice. Microorganisms were given i.p. to CBA mice aged 17 months. After treatment with microorganisms, animals showed increases in motor activity, muscle strength (the load-lifting test), the feeding instinct (the(More)
It has been established that lymphoid tissue involution caused by mixed experimental tuberculosis-opisthorchiasis infection was accompanied by a considerable attenuation of fibrosis and less intensive inflammatory destructive changes and liver fibrosis, as compared to monoinvasion with opisthorchis. In mixed infection there was a decrease in(More)
Microorganisms of genus Bacillus strain 3M (permafrost microorganisms--PM), allocated from the samples of permafrost soils from Mamontova Mountain (Yakutia) are influenced by the quality and duration of life of elderly mice. PMs were injected intraperitoneally to CBA mice at the age of 17 months. Motion activity, muscular force (lifting of cargo test), food(More)