292 It is known that the respiration rate and ATP synn thesis in the mitochondria isolated from ischemic carr diac tissue is fairly low. Oneeelectron oxygen reduction leads to the generation of superoxide and other reacc tive oxygen species (ROS), which occurs in different parts of the respiratory chain . The events that take place in the mitochondria… (More)
The existence of lipid-radical cycles in membranes as an LPO alternative has been proven. Cytochrome b5 seems to play the key role in the formation of these cycles. The functional role of lipid-radical cycles in cell metabolism, including the positive effect on microsomal and mitochondrial oxidation, is discussed.