L. F. A. Wessels

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MicroRNAs (miRNA) regulate many genes critical for tumorigenesis. We profiled miRNAs from 11 normal breast tissues, 17 noninvasive, 151 invasive breast carcinomas, and 6 cell lines by in-house-developed barcoded Solexa sequencing. miRNAs were organized in genomic clusters representing promoter-controlled miRNA expression and sequence families representing(More)
This paper reports the results of the development, deployment and testing of a large spoken-language dialogue application for use by the general public. We built an automated spoken questionnaire for the U.S. Bureau of the Census. In the project's rst phase, the basic recognizers and dialogue system were developed using 4,000 calls. In the second phase, the(More)
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Several gene expression signatures have been proposed and demonstrated to be predictive of outcome in breast cancer. In the present article we address the following issues: Do these signatures perform similarly?(More)
Fragile error handling in recognition-based systems is a major problem that degrades their performance, frustrates users, and limits commercial potential. The aim of the present research was to analyze the types and magnitude of linguistic adaptation that occur during spoken and multimodal human-computer error resolution. A semiautomatic simulation method(More)
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