L. Everett Seyler

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The present study explored neuropeptide responses to nicotine from smoking. Habitual smokers smoked research cigarettes of known strength under controlled laboratory conditions while blood samples were withdrawn unobtrusively for subsequent biochemical analysis. To provide a metric that reflected total nicotine intake and total neurohormonal output, data(More)
Nausea was induced by having subjects smoke two high nicotine cigarettes in quick succession. Plasma levels of prolactin, adrenocorticotropic hormone, beta-endorphin/beta-lipotropin, growth hormone, arginine vasopressin, and neurophysin I increased without changes in thyroid stimulating hormone, luteinizing hormone, or follicle stimulating hormone. Nausea(More)
The urea clearance test developed by M6ller, McIntosh and Van Slyke (1) has one disadvantage, namely, that maximum and standard clearances are only comparable by refer.ence to the average normal value for each or by multiplying the standard clearance by a constant. In addition the standard clearance, involving the square root of the urine volume, is(More)
The relationship among changes in plasma nicotine, ACTH, and cortisol secretion after smoking were investigated. Ten male subjects smoked cigarettes containing 2.87 mg nicotine and 0.48 mg nicotine. No rises in cortisol or ACTH were detected after smoking 0.48 mg nicotine cigarettes. Cortisol rises were significant in 11 of 15 instances after smoking 2.87(More)
To determine whether female transsexuals have abnormal hypothalamic-pituitary feedback control, pituitary LH and FSH secretory responses to synthetic LRH (100 micrograms iv) were measured in nine female transsexuals with normal menstrual cycles before and after a 7-day course of treatment with diethylstilbestrol (DES; 2 mg/day). Control groups included five(More)
The disappearance rates of the biologic activity of synthetic LRH have been measured in normal and hypogonadal men before and during estrogen treatment. Biologic activity was assayed by the change in radioimmunoassayable rat LH levels induced by injection of human plasma into ovariectomized rats pretreated with estrogen and progesterone, and compared with a(More)