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The yeastlike form of Paracoccidioides brasiliensis strain IVIC Pb9 reduced the amount of alpha-1,3-glucan in its cell wall from 45 to 3% when subcultured in vitro for several years. This strain regained its alpha-1,3-glucan up to 25% of the total cell wall when grown in vivo. A mutant strain of P. brasiliensis Pb9, named IVIC Pb140, reported to have(More)
An adenine-requiring mutant of Paracoccidioides brasiliensis strain IVIC Pb9 was isolated after treatment of the yeast-like (Y) form with nitrosoguanidine. Cell wall analysis of this mutant (strain IVIC Pb141) showed an increase in the amount of alpha-1,3-glucan and a virtual disappearance of the antigenic galactomannan. At the same time, a higher degree of(More)
Interferon-gamma (IFN-gamma), a glycoprotein secreted by antigen-or mitogen-activated lymphocytes, modulates the activities of lymphocytes and macrophages. For mouse macrophages, murine IFN-gamma (MuIFN-gamma) stimulates several functions, including phagocytosis, tumoricidal activity, and the increased expression of Ia and H-2 antigens of the major(More)
Blood form trypomastigotes of the Y strain of T. cruzi, produced a strong inhibition of the blastogenic response to T and B cell mitogens, of the C3H/He, C57BL/6 and BALB/cJ strains of mice, while culture epimastigotes of the Y strain kept in a medium that allows parasite growth at 26 degrees, 30 degrees, 34 degrees and 37 degrees C produced a strong(More)
Antisera to epi- and trypomastigote forms of Trypanosoma cruzi were used to detect trypanosome antigens on the surface of lymphocytes from infected mice. Only the anti-trypomastigote serum could recognize antigens expressed transiently on the splenocyte membranes from infected animals. The number or structural configuration of Concanavalin A receptors was(More)
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