L. E. Aseeva

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As revealed in this study, metabolic acidosis is observed in experimental animals the influence of "murine" toxin and Y. pestis fraction I, which is manifested by the parameters of the acid-base state, the gas composition of blood and the content of electrolytes.
The state of the functional activity of peritoneal leukocytes from different species of gerbils (Mongolian gerbils, Libyan jirds, as well as gerbils inhabiting the right and left banks of the Volga), exposed to the action of Y. pestis capsular antigen, has been found to correlate with the susceptibility of these animals to plague.
Neuraminidase isolated from Yersinia pestis [correction of the plaque microbe] and purified has been studied for its effect on the peritoneal leukocytes of the white mice with results presented. Neuraminidase exerted the insulin-like effect on the peritoneal leukocytes of the white mice and this effect depended on the used dose. The priming of leukocytes by(More)
Effects ofYersinia pestis capsular antigen and toxin on the cells of experimental antimals are described. The antigen of bacterial fraction I enhanced the oxidative burst of white mice peritoneal leukocytes but suppressed the activity of guinea pig leukocytes. The effect of “murine” toxin was quite the contrary. Moreover, the effects of the toxin on the(More)
AIM To study nature of changes in components of glutathione disulfide system of experimental animals influenced by plague "murine" toxin. MATERIALS AND METHODS Total glutathione level as well as levels of oxidated (G-SS-G) and reduced (GSH) forms of glutathione, activity of glutathione reductase and glutathione peroxidase in erythrocytes of Mongolian(More)
The influence of hydrogen peroxide on the dynamics of transition into uncultivable state (UCS) and on the reversion of V. cholerae and their subcultures, resistant to hydrogen peroxide, was studied. The transition of the initial cultures in river and distilled water into UCS took place earlier than that in resistant to hydrogen peroxide variants. The(More)
The effect of purified preparation of adenylate cyclase isolated from Y. pestis on peritoneal leukocytes of white mice and guinea pigs was investigated. Y. pestis adenylate cyclase was shown to accomplish its pathogenic action via histamine-specific receptors on the surface of eukaryotic cells. The involvement of H1 and H2 histamine receptors on target(More)
The biological action of Y. pestis adenylate cyclase on peritoneal leukocytes of guinea pigs has been studied by means of chemiluminescence. Y. pestis adenylate cyclase is supposed to contribute to the "oxidation" explosion of phagocytes in plague.