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This paper describes the application of Dis-tributional Clustering [20] to document classification. This approach clusters words into groups based on the distribution of class labels associated with each word. Thus, unlike some other unsupervised dimensionality-reduction techniques, such as Latent Semantic Indexing, we are able to compress the feature space(More)
Glucose is the brain's principal energy substrate. In Alzheimer's disease (AD), there appears to be a pathological decrease in the brain's ability to use glucose. Neurobiological evidence suggests that ketone bodies are an effective alternative energy substrate for the brain. Elevation of plasma ketone body levels through an oral dose of medium chain(More)
OBJECTIVE To examine the effects of intranasal insulin administration on cognition, function, cerebral glucose metabolism, and cerebrospinal fluid biomarkers in adults with amnestic mild cognitive impairment or Alzheimer disease (AD). DESIGN Randomized, double-blind, placebo-controlled trial. SETTING Clinical research unit of a Veterans Affairs medical(More)
OBJECTIVES To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response. DESIGN Six-month, randomized, controlled, clinical trial. SETTING Veterans Affairs Puget Sound Health Care System(More)
OBJECTIVE To determine the relationship between exogenous testosterone administration and cognitive abilities in a population of healthy older men. BACKGROUND Serum levels of total and bioavailable testosterone gradually decrease with age in men and are associated with reductions in muscle mass, osteoporosis, decreased sexual activity, and changes in(More)
Raising insulin acutely in the periphery and in brain improves verbal memory. Intranasal insulin administration, which raises insulin acutely in the CNS without raising plasma insulin levels, provides an opportunity to determine whether these effects are mediated by central insulin or peripheral processes. Based on prior research with intravenous insulin,(More)
Glucose utilization appears to play a role in memory, and patients with Senile Dementia of the Alzheimer Type (SDAT) show particular abnormalities of the glucose system. The present study examined the effects of glucose administration on memory in subjects with mild SDAT and age-matched controls. SDAT subjects demonstrated greater overall increases in blood(More)
A meta-analysis of 27 primary studies was conducted to examine the relationship between neuropsychological functioning and driving ability for adults with dementia. When studies using a control group were included, the relationship between cognitive measures and on-road or non-road driving measures was significant for all reported domains; mean correlations(More)
Preliminary evidence from clinical studies indicates that treatment with estrogen augments cognitive function for women with Alzheimer's disease (AD). The neurobiology of estrogen, particularly its neuromodulatory and neuroprotective actions, provide a viable basis to support such cognition-enhancing effects. We conducted a placebo-controlled, double-blind,(More)
OBJECTIVE To compare the effects of a 4-week high-saturated fat/high-glycemic index (HIGH) diet with a low-saturated fat/low-glycemic index (LOW) diet on insulin and lipid metabolism, cerebrospinal fluid (CSF) markers of Alzheimer disease, and cognition for healthy adults and adults with amnestic mild cognitive impairment (aMCI). DESIGN Randomized(More)