L. D. Miller

Learn More
Previously, we showed that Src tyrosine kinases are activated early in the development of human colon cancer and are suppressed as intestinal cells differentiate. We identified RACK1 as an endogenous substrate, binding partner and inhibitor of Src. Here we show (by overexpressing RACK1, depleting Src or RACK1 and utilizing cell-permeable peptides that(More)
RACK1 is the founding member of a family of receptors for activated C kinase collectively called RACKs. Upon activation of PKC, RACK1 co-localizes with the Src tyrosine kinase at the plasma membrane and functions as a substrate, binding partner and inhibitor of Src (as measured in vitro), and a growth inhibitor in NIH 3T3 cells. To further analyze the(More)
Cascades of kinases and phosphatases are regulated by selective protein-protein interactions that are essential for signal transduction. Peptide modulators of these interactions have been used to dissect the function of individual components of the signaling cascade, without relying on either the over- or underexpression of proteins. Previously, we(More)
A simple hand-held instrument has been designed and constructed to nondestructively estimate above-ground gramineous biomass using radiometric measurements. The prototype unit consists of a modified two-channel digital radiometer interfaced to a pocket calculator. A digital interface was constructed to join electronically and control the radiometer and(More)
We demonstrate a novel all-fiber resonant optical cavity which uses two-fiber reflectors, each formed by a single loop of fiber between the output ports of a fiber directional coupler. The reflectivities of the fiber mirrors are each determined by the coupling ratio and the insertion loss of the fused couplers. When the cavity is formed in this way using a(More)
Small angle X-ray scattering (SAXS) and atomic force microscopy (AFM) measurements have been shown to be consistent with the presence of nanofibrils in the cocoon silk of Bombyx mori and the dragline silk of Nephila clavipes. The transverse dimensions and correlation lengths range from >> 59 to 220 nm and in the axial direction from >> 80 to 230 nm. Also,(More)
  • 1