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The influence of semicarbazide (SC), an inhibitor of glutamate decarboxylase (GDC), on electrical and respiratory activity of the Purkinje cells and cortical neurons of mice was investigated in tissue culture. A biphase character of the SC influence on the investigated parameters was demonstrated. The first excitatory phase could be produced by the blocking(More)
The Fourier spectre of power (SP) and bioelectrical activity of the cortex, hippocampus and hypothalamus were studied in unrestrained rats with high (HR) and low (LR) resistance to oxygen deficiency before and after their stay at the "altitude" of about 11,000 m. After acute hypobaric hypoxia there were the EEG changes in LR rats: displacement of the SP(More)
The Fourie EEG spectral analysis of thr sensomotor cortex and dorsal hypocampus in freely moving rats could reveal the common pharmacological EEG effects of different antihypoxic agents (gutimin, amtizole, emoxipine, and 3-OPK). All the agents decreased the total EEG power (they all reduced the absolute power in all frequency bands) and simultaneously(More)
Spontaneous electrical activity, adenyl nucleotides' and cytochromes' contents, activity of respiratory chain enzymes complex in brain slices, homogenate and isolated mitochondria of rats, preliminary divided into non-resistant (NR) and high resistant (HR) animals by their sensitivity to hypobaric hypoxia have been investigated. It has been shown that in HR(More)
The effects of some antihypoxants (piracetam, GABA, sodium hydroxybutyrate and gutimine) on the electrical activity of the cerebellar neurons (Purkinje cells) of rats and mice were studied in the surviving slices under normoxia and increasing hypoxia. All the agents were found to produce phase changes in the base-line electrical activity of neurons:(More)
Non-strain albino rats with the active type of behaviour (high motor activity and often visiting the center in the "open field" test) were found to be characterized by the longer time of survival at lifting to 11,000 m than the animals with the passive type of behaviour (low motor activity and lesser number of center visits). The latter were observed to(More)
Decrease of the pO2 led to the same phasic changes in the unit activity of Purkinje cells and hippocampal neurons in mice. Purkinje cells proved to be more resistant against oxygen deficiency in tissue culture than in surviving slices. Cells of the optic cortex preserved high level of functional activity at lowering the pO2 to 50%. Still, they were more(More)
Respiration and oxidative phosphorylation of brain mitochondria were studied in outbred rats with different types of behaviour in open-field test and in forced swimming test. It was found that in rats with "active" type of behaviour (with high locomotor activity and low level of depressiveness) the brain mitochondria have at succinate oxidation a higher(More)