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The influence of semicarbazide (SC), an inhibitor of glutamate decarboxylase (GDC), on electrical and respiratory activity of the Purkinje cells and cortical neurons of mice was investigated in tissue culture. A biphase character of the SC influence on the investigated parameters was demonstrated. The first excitatory phase could be produced by the blocking(More)
A bioenergetic mechanism for development of urgent adaptation to hypoxia is considered. Hypoxia induces reprogramming of respiratory chain function and switching from oxidation of NAD-related substrates (complex I) to succinate oxidation (complex II). Transient, reversible, compensatory activation of respiratory chain complex II is a major mechanism of(More)
The Fourier spectre of power (SP) and bioelectrical activity of the cortex, hippocampus and hypothalamus were studied in unrestrained rats with high (HR) and low (LR) resistance to oxygen deficiency before and after their stay at the "altitude" of about 11,000 m. After acute hypobaric hypoxia there were the EEG changes in LR rats: displacement of the SP(More)
The mitochondrial respiratory chain participates in the performance of the signal system, which activates the realization of metabolic compensatory processes and coupled functional response to both single and repeated, long-term exposure to acute hypoxia. Under the conditions of reduced oxygen delivery to cells the mitochondrial respiratory chain is(More)
The Fourie EEG spectral analysis of thr sensomotor cortex and dorsal hypocampus in freely moving rats could reveal the common pharmacological EEG effects of different antihypoxic agents (gutimin, amtizole, emoxipine, and 3-OPK). All the agents decreased the total EEG power (they all reduced the absolute power in all frequency bands) and simultaneously(More)
Biochemical parameters characterizing visceral functions were measured in the plasma of rats with brain ischemia induced by double occlusion of the carotid arteries. Functional insufficiency of the viscera is gradually forming in the course of occlusive ischemia of the brain. Functional insufficiency of the liver was observed in animals with severe(More)
It was found that infrared laser radiation (IRL) reduces the sparing action of acute hypoxia on ventricular transport function of low-resistant animals and accelerates the recovery of the function during the post-hypoxia period. The effect was caused by the IRL affecting directly the speed of perfusion through the myocardium and thus the latter's breathing(More)
The effect of hypoxia of middle severity (H50) has been investigated on the contractile activity, oxidative metabolism and bioenergetic function of the myocardium in the isolated rat heart. It has been shown that differences in the functional-metabolic parameters sensitivity in the resistant and non-resistant to hypoxia animals are defined by the primary(More)
Spontaneous electrical activity, adenyl nucleotides' and cytochromes' contents, activity of respiratory chain enzymes complex in brain slices, homogenate and isolated mitochondria of rats, preliminary divided into non-resistant (NR) and high resistant (HR) animals by their sensitivity to hypobaric hypoxia have been investigated. It has been shown that in HR(More)
Spontaneous destruction of cytochrome P-450 arising from activation of lipid peroxidation (LPO) occurs during incubation of hepatocytes. LPO activation in hepatocyte suspension by a catalytic system containing Fe2+--ADP plus NADP X H makes the destruction of cytochrome P-450 more rapid. Supplementation of the incubation medium with the antioxidant,(More)