L. D. Chen

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Exogenously administered melatonin causes a 2-fold rise in glutathione peroxidase activity within 30 min in the brain of the rat. Furthermore, brain glutathione peroxidase activity is higher at night than during the day and is correlated with high night-time tissue melatonin levels. Glutathione peroxidase is thought to be the principal enzyme eliminating(More)
Melatonin protection against in vitro kainic acid-induced oxidative damage in homogenates from different rat brain regions is shown. Brain-disrupted cell homogenates from cerebral cortex, cerebellum, hippocampus, hypothalamus, and corpus striatum were incubated with kainate (11.7 mM) with or without different concentrations of melatonin (0.1-4 mM). The(More)
This paper presents an overview of the National Advanced Driving Simulator (NADS), its design, and core capabilities. The NADS is a high-fidelity driving simulator whose goal is to investigate human-centered issues as they relate to driving safety. Its primary mission is to investigate causes of accidents, with the goal of reducing fatalities on U.S.(More)
This paper presents a framework for understanding IS evaluation in its broader context. The role of IS evaluation is emphasised on integrating the IS development process into business development process. The framework is applied to analyze a single IS project in details. The results show that sometimes formal IS evaluation might not be important or(More)
Pineal gland N-acetyltransferase (NAT) activity and pineal and serum levels of melatonin declined linearly in albino rats acutely exposed to different intensities of red light (600 nm or higher; low, 140 microW/cm2; moderate, 690 microW/cm2; high, 1200 microW/cm2) during the middle of the night. The high intensity red light was as effective as white light(More)
The effect of pulsed static magnetic fields on the rat pineal melatonin synthesis was studied at different times of the photoperiod. Exposure to magnetic fields during mid- or late dark phase significantly suppressed pineal N-acetyltransferase activity, the rate-limiting enzyme in melatonin synthesis, as well as the melatonin content in the pineal gland.(More)
©2013 iii Acknowledgements Thank you Peter Bronk for guiding me through the projects, expanding my understanding about research, and encouraging me to try my best. Abstract Electrophysiological studies of eag mutants with defective regulation by CaM and CaMKII A thesis presented to the Biochemistry Department The Drosophila melanogaster ether-à-go-go (EAG)(More)
[Ca(2+)+Mg2+]-dependent ATPase activity in the pineal gland of the rat was examined. The enzyme possesses an apparent Km (Ca2+) of 0.23 microM, and moderately high affinity for Mg2+ and ATP (Km = 53.2 microM and Km = 86.4 microM, respectively). The ATPase activity is sensitive to low concentrations (I50 approximately 1 microM) of vanadate, which(More)
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