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Single motor unit (MU) action potentials were recorded from the flexor carpi ulnaris during its weak voluntary contraction in 6 healthy subjects. At low frequencies of motoneuronal firing (the average interspike interval ranged from 70 +/- 8 to 200 +/- 22 msec), double discharges with interspike intervals from 5 to 20 msec were seen from about one-fourth of(More)
The activity of single motoneurones of m. flexor carpi ulnaris (FCU) was investigated by recording their motor unit (MU) action potentials during weak and moderate voluntary muscle contractions. The MU firing rate range was 4.5–15 imp/s. The excitability of motoneurones was tested with a number of single stimuli eliciting a monosynaptic H-reflex of low(More)
We investigated the effect of reciprocal inhibition upon single firing motoneurons of the human soleus and ex. carpus uln. A computer simulation of the effect of an inhibitory volley upon motoneuron impulse activity was carried out on the basis of our own data and data in the literature [3, 4]. It was shown that the duration of the silent period (SP), i.e.,(More)
The main shortcoming of modern antitumor chemotherapy, which utilizes chiefly cytotoxic drugs, lies in their extremely high toxicity towards normal cells with a rapid turnover rate, from the hemopoietic, immune, and reproductive systems and the epithelium of the gastrointestinal tract [i, 2]. Therefore, increasing the therapeutic index of antitumor drugs is(More)
The aim of this investigation was to determine a program of regular injection of a phasespecific cytotoxic agent, causing minimal damage to hematopoietic stem cells (CFUs)~ It is easy to see that during periodic administration of a phase-specific agent on a homogeneous population of dividing cells, minimal damage will take place if the interval between(More)
The influence of a short inhibitory volley on firing motoneurons of soleus and ext. carpi uln. was studied in human experiments and the results obtained were used as a basis for simulation. An increase of the interspike interval (ISI) depended on the timing of inhibitory volley arrival and silent period (SP) duration was studied. The ability of the(More)
Single motor unit potentials of the flexor carpi ulnaris muscle were recorded during voluntary contraction and H-reflex was evoked. The afferent volley effectiveness was estimated by the firing index of a motoneuron. The background firing rate of motor units ranged from 3.3 to 16.0 imp/s. Afferent volley effectiveness depended on the background firing rate(More)
In the absence of external effects, the random destruction and passage of normal stem cells to differentiation are compensated by their multiplication, so that under normal conditions the population of these cells is present in a stationary state because of regulative feedbacks. The main feature of the population of tumorigenic cells is their unlimited(More)
Spatial heterogeneity was simulated by a 2-fold increase in either of gNa, gK, g1 in the central part of the fibre. The interval-dependent conduction block was not observed in the cable with normal gNa, while the uniform decrease in gNa along the fibre resulted were the block appearance. Difference in the refractory period of these parts of the fibre were(More)
The main disadvantage of modern antitumor chemotherapy is the high toxicity of the cytotoxic agents used relative to normal, rapidly proliferating tissues, including "critical" tissues and cells such as hematopoietic tissue and intestinal enterocytes [i]. One approach to increased selectivity of antitumor agents is protection of the stem cells of normal(More)