L. Churikova

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Single motor unit (MU) action potentials were recorded from the flexor carpi ulnaris during its weak voluntary contraction in 6 healthy subjects. At low frequencies of motoneuronal firing (the average interspike interval ranged from 70 +/- 8 to 200 +/- 22 msec), double discharges with interspike intervals from 5 to 20 msec were seen from about one-fourth of(More)
The activity of single motoneurones of m. flexor carpi ulnaris (FCU) was investigated by recording their motor unit (MU) action potentials during weak and moderate voluntary muscle contractions. The MU firing rate range was 4.5–15 imp/s. The excitability of motoneurones was tested with a number of single stimuli eliciting a monosynaptic H-reflex of low(More)
Spatial heterogeneity was simulated by a 2-fold increase in either of gNa, gK, g1 in the central part of the fibre. The interval-dependent conduction block was not observed in the cable with normal gNa, while the uniform decrease in gNa along the fibre resulted were the block appearance. Difference in the refractory period of these parts of the fibre were(More)
The main shortcoming of modern antitumor chemotherapy, which utilizes chiefly cytotoxic drugs, lies in their extremely high toxicity towards normal cells with a rapid turnover rate, from the hemopoietic, immune, and reproductive systems and the epithelium of the gastrointestinal tract [i, 2]. Therefore, increasing the therapeutic index of antitumor drugs is(More)
The influence of a short inhibitory volley on firing motoneurons of soleus and ext. carpi uln. was studied in human experiments and the results obtained were used as a basis for simulation. An increase of the interspike interval (ISI) depended on the timing of inhibitory volley arrival and silent period (SP) duration was studied. The ability of the(More)
Dynamic behavior of stem cells population of the "critical" tissue (normal population) and tumor cell population under periodic treatment with a phase-specific cytotoxic agent was considered. The results were used for optimization of anticancer chemotherapy. The schedules of treatment were found which provide a maximum rate of tumor-cell elimination for any(More)
The dependence was studied between the survival of proliferating hemopoietic stem cells (CFUs) on the interval between regular multiple injections of hydroxyurea (HU). Before HU injection mice were irradiated in a dose of 200 rad to trigger the proliferation of CFUs. The dependence obtained is resonance in character, with a maximum being attained during(More)
The main disadvantage of modern antitumor chemotherapy is the high toxicity of the cytotoxic agents used relative to normal, rapidly proliferating tissues, including "critical" tissues and cells such as hematopoietic tissue and intestinal enterocytes [i]. One approach to increased selectivity of antitumor agents is protection of the stem cells of normal(More)
A study was made of the effect of reciprocal inhibition on individual firing motoneurons in the extensor carpi ulnaris and soleus muscle in human subjects. Peristimulus histograms (PSH) were plotted at different average frequency of motoneuron firing ( $$\bar f$$ ) and the change in duration of interspike intervals (ISI) was analyzed. For reciprocal(More)
Reciprocal inhibition (RI) has been studied for its effect on repetitive firing of single motoneurons in the extensor carpi ulnaris and soleus muscles of healthy subjects. The peristimulus time histograms (PSTHs) were plotted for different mean firing frequency of motoneurons. Changes in the interspike interval duration were analyzed. It was shown that the(More)