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Sex hormone-binding globulin (SHBG) is a protein that binds certain androgens and estrogens with high affinity (1, 2) and restricts the access of such steroids to tissues as long as the steroids remain bound to SHBG (3). Measurements of SHBG are often done on a clinical basis and can be used to determine the amounts of free and bioavailable estradiol and(More)
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