L. Bouyard

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The aim of the present study was to investigate an eventual influence of the hour of administration on lidocaine kinetics in the rat. 280 Wistar AF-SPF adult male rats were used for this study and maintained under controled environmental conditions (LD : 06.00–18.00) during the month of October. A single 50 mg.kg−1 dose of lidocaine was given by(More)
The purpose of the present study was to investigate whether the time of day (24 h) at which carbamazepine is administered influences its pharmacokinetics in the rat. The pharmacokinetics of a single, 100 mg.kg−1 bodyweightper os, dose of carbamazepine were studied at four different fixed time points of a 24-hour period (i.e. 10.00, 16.00, 22.00 or 04.00 h)(More)
The comparative study of 4 Benzamides effects on the oestrus cycle of female rats has been done. These compounds were administered once daily for 21 consecutive days (1; 0,1; and 0,001 mg.kg-1.SC) on Wistar AF SPF rats smears. Our data show that sulpiride and sultopride suppress oestrus cycle substituted by a permanent dioestrus, while metoclopramide only(More)
1. The aim of the present study was to investigate an eventual influence of the hour of administration on lidocaine kinetics in the rat. 280 Wistar AF SPF adult male rats were used for this study and maintained under controlled environmental conditions (LD: 06.00-18.00) during the month of October. A single 50 mg . kg-1 dose of lidocaine was given by(More)
A comparative study of two antiemetic neuroleptics, metoclopramide and metopimazine, effects on the oestrus cycle of female rats has been done. These compounds were administered once daily for 21 consecutive days (1, 0,1, 0,01, 0,001 mg/kg/s.c.) on Wistar AFSPF rats, exhibiting regular four day cycles. Evolution of oestrus cycle was studied by daily vaginal(More)
1. We previously reported circadian variations of pharmacokinetic parameters of lidocaine in the rat after a single 50 mg.kg-1. I.M. dose of this drug administered at four different fixed time points of a 24-hours period (i.e.: 10.00, 16.00, 22.00 or 04.00 h). As diurnal variations of membrane permeability was one of the suggested hypothesis, we(More)