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Metastatic melanoma cells express a number of protein tyrosine kinases (PTKs) that are considered to be targets for imatinib. We conducted a phase II trial of imatinib in patients with metastatic melanoma expressing at least one of these PTKs. Twenty-one patients whose tumours expressed at least one PTK (c-kit, platelet-derived growth factor receptors,(More)
7528 Background: Imatinib mesylate (Gleevec™), an oral inhibitor of phosphorylation of certain tyrosine kinases (TK), is active in gastrointestinal stromal tumors which are chemotherapy resistant. Perhaps MM may respond to Gleevec, especially if the tumor cells or microenvironment express one of the known TK targets: KIT, PDGF receptors α or β, c-abl, or(More)
Inflection class features that assign noun stems to declensional classes are peculiar objects. On the one hand, nominal inflection class features seem to be indispensable in analyses of noun inflection systems in various IndoEuropean languages (like Spanish, Greek, and Russian). On the other hand, nominal inflection class features differ from other,(More)
We present a framework for modeling the spread of pathogens throughout a population and generating policies that minimize the impact of those pathogens on the population. This framework is used to study the spread of human viruses between cities via airplane travel. It combines agent-based simulation, mathematical analysis, and an Evolutionary Algorithm(More)
To determine whether texturing and coating have additive effects in promoting tissue integration and inhibiting fibrosis, we evaluated smooth silicone rubber (SSR), textured silicone rubber (TSR), porous silicone rubber (PSR), expanded polytetrafluoroethylene (ePTFE), and porous polyurethane (PPU) subcutaneous implants in eight minipigs. Some of the(More)
This study proposes an Optimality-theoretic model through which the various grammar components—semantics, syntax, the lexicon, morphology, and prosody—jointly determine the placement of clitics with a phrasal positioning domain, which is either a nominal expression or a clause. In order to render scope, such clitics must be phrase-initial. However, the(More)
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