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In this paper, the authors report the results of a genetic-diagnostic survey of 262 instutionalized moderately mentally retarded patients and compare these data with their previous studies of the severely mentally retarded. Special attention is given towards the nosology of X-linked mental retardation and familial mental retardation in general.
Two adult, mentally retarded males with the typical features of the Coffin-Lowry syndrome are reported. Further family investigation led to the same diagnosis in a 2.5-year-old male cousin, and to the identification of five female carriers, with variable clinical expression of this X-linked inherited mental retardation syndrome.
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