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The primary objective of this study was to investigate structural changes, as measured by joint space narrowing (JSN), within the knee joint during treatment with intra-articular sodium hyaluronate (HA) of molecular weight 500-730 kDa in patients with osteoarthritis (OA) of the knee. Patients received a weekly intra-articular injection of either 20 mg2/ml(More)
The effect of chronic administration of phosphatidylserine derived from brain cortex on the neuroendocrine responses to physical stress has been examined in a placebo-controlled study in 9 healthy men. Phosphatidylserine 800 mg/d for 10 days significantly blunted the ACTH and cortisol responses to physical exercise (P=0.003 and P=0.03, respectively),(More)
The activity of brain cortex-derived phosphatidylserine (BC-PS) on the neuroendocrine and neurovegetative responses to physical stress was tested in 8 healthy men who underwent three experiments with a bicycle ergometer. According to a double-blind design, before starting the exercise, each subject received intravenously, within 10 min, 50 or 75 mg of BC-PS(More)
The antisecretory effects of esaprazole on basal gastric secretion and on pentagastrin-stimulated secretion (6 micrograms/kg subcutaneously) were evaluated in two trials carried out on 19 healthy volunteers. All trials were carried out according to a randomized double-blind crossover design versus a placebo. The oral administration of 900 mg of esaprazole(More)
A randomized controlled study was done on 60 patients, divided into three groups, who underwent extracapsular cataract extraction and intraocular lens implantation. The aim of the study was to investigate the effect on postoperative intraocular pressure (IOP) of IAL left in situ compared with IAL or Healon removed after surgery. The IOP was monitored three,(More)
The activity and tolerability of esaprazole administered once a day at doses of 900 and 1350 mg/day in the treatment of gastric ulcer were evaluated in a preliminary study carried out in 47 patients. The results failed to show any difference between the two doses in terms of percentage of ulcer healing after 4 weeks (43% and 45% respectively) or 8 weeks(More)
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