L B Wolosin

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The objective of this study was to investigate whether natural anti-tumor antibodies (NAb) contributed to the surveillance of small inocula of syngeneic tumors. Experiments were designed to distinguish between NAb and NK-mediated host resistance. Four approaches were used: (1) the isolation of tumor variants differing in their tumorigenicity and(More)
A concurrent study of specificity, regulation, ontogeny, and genetics of murine natural killer (NK) cell and natural antibody (NAb) activities [in DBA/2, CBA/J, A/Sn, and A/J inbred mice, Bg/Bg + mice of the inbred C57BL/6J background, (C57BL/6 x DBA/2) F1 mice, and (CBA x DBA/2) F1, (A/Sn x DBA/2)F1, and (A/J x DBA/2)F1 mice] revealed that : a) The(More)
A competitive radioimmunoassay (RIA) for the detection of cell-bound antibody was used to study the in vivo acquisition of immunoglobulin (Ig) by tumor cells. Several tumor lines acquired Ig rapidly between 3 and 18 h after intraperitoneal implantation into normal syngeneic mice and this Ig was recovered by elution with basic or acid buffers. The Ig eluted(More)
The genetics of natural antitumor antibodies was studied in several murine strains with 4 target tumors. We found that the levels of NAb detected depended on the strain-tumor combination and that high levels of NAb were inherited recessively. These observations suggested that NAb specificities are selectively regulated. Studies of backcross progeny and of(More)
Antibody dependent lymphocytotoxicity has been characterized in cytolytic, cytostatic and microcytotoxicity assay. A " null " K cell was found in all assays and has been identified as a non phagocytic, non adherent, intermediate sized cell of lymphoid-like morphology with Mg++-independent C' receptors, lacking both T and B lymphocyte membrane antigens. In(More)
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