L. B. Gorbacheva

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The antitumor activity of sesquiterpene lactones of the germacrane series was discovered in 1970s [1]. (10)-Epoxy-5,7(H),6,11 (H)-guai-3(4)-11(12)-dien-6(12)-olide (I, arglabin), representing sesquiterpene -lactones of the guaiane type 1, was originally isolated in 1980 from Artemisia glabella Kar. et Kir., an endemic wormwood species occurring in Central(More)
A comparative study on the genotoxic activity of cisplatin versus morfozol, the first representative of a new class of cation-anion complexes of palladium [AH]2[PdCl4] (where A-methylmorpholine) has been performed using human lymphocytes in vitro. The results of the DNA-DNA cross-linking activity investigations showed that both compounds studied exhibited(More)
Ribonucleotide reductase activity (RRA) has been studied in various tumors and spleens of tumor-bearing animals using EPR technique and biochemical methods. The effect of a number of biologically active compounds on RRA has also been studied. RRA in tumor and spleen increases during tumor growth. Inhibitory effect of irradiation, hydroxyurea,(More)
UNLABELLED The aim of this work is to study responses of PHA-stimulated and resting lymphocytes to methylating agent N-methyl-N-nitrosourea (MNU) and to compare sensitivity to this agent of healthy donor lymphocytes and lymphocytes from patients with gynecological cancers. METHODS Cytotoxicity of MNU, apoptotic death of lymphocytes, was evaluated using(More)
Melanoma is a highly aggressive neoplastic disease attributed to transformed melanocytes. The efficacy of regimens of cytotoxic chemotherapy for advanced stage patients does not exceed 20%. Search for lymphocyte markers of patients' sensitivity to chemotherapy provides a rational basis for development of cytotoxic chemotherapy. Using blood lymphocytes we(More)
The pool of low-molecular-weight metabolites was studied in patients with breast cancer by high-resolution1H-NMR spectroscopy. In order to predict the efficiency of treatment, mathematical regression analysis was carried out with consideration for some clinical morphological characteristics of patients, chemotherapy protocols, and the degree of therapeutic(More)
SUMMARY A single injection of nitrosomethylurea (80 mg/kg body weight) to mice bearing hepatoma 22a led to an injury of the main components of the protein-synthesizing system (poly ribosomal complex and soluble factors of the cell sap) in liver and hepatoma cells. In liver cells of adult animals, the activity of the protein-synthesizing system returns to a(More)
O6-Methyl-2'-deoxyguanosine (O6-MedG), a novel inhibitor of O6-alkylguanine-DNA alkyltransferase (O6-AGT), has been synthesized. The ability of O6-MedG to deplete the O6-AGT activity in leukemia L1210 and melanoma B16 cells in vivo has been studied. After intraperitoneal administration of O6-MedG to mice bearing leukemia L1210 or melanoma B16, the activity(More)