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Chronic psychoemotional stress of social defeats produces development of experimental anxious depression in male mice similar to this disorder in humans. 5-HT and 5-HIAA levels, TPH and MAO A activities, 5-HT1A-receptors in different brain areas were investigated at different stages of development of experimental disorder. It has been shown that initial(More)
The role of genetic and seasonal factors in stress-induced changes of pain sensitivity, evaluated by latency in hot plate test was studied. Significant interstrain differences in restriction effect on pain sensitivity was established. Analgesia, hyperalgesia or lack of influence on pain sensitivity in mice of different strains was observed in response to(More)
In mice with different experience of agonistic confrontations: victories or social defeats during 3 and 10 days (T3 and T10 winners and T3 and T10 losers, resp.), T10 winners displayed a lesser aggression and a more hostile behaviour than T3 winners. Naltrexone dose-dependently decreased attacks in the T3 winners and did not affect aggressive grooming,(More)
The authors studied the effect of naltrexone (0.25 and 1.0 mg/kg, intraperitoneal injection) on the communicative and aggressive behavior of male C57BL/6J mice with experience in triumphs in 20 tests (victors) and of mice without such experience (novices). The level of communicativeness and aggression at the first confrontation was more marked in novices(More)
It has been shown that corticosteroid content of the blood in hibernating ground squirrels is the lowest. In spring, before the arousal, some increase in corticosteroid content is observed, although the latter remains lower than that in non-hibernating animals. During the arousal, corticosteroid content of the blood in the ground squirrels increased slowly(More)
The effect of single severe stress in the form of forced swimming on the behavior of males and females in the mouse inbred strains CBA/Lac and C57BL/6J were examined in the open field test. Measurements were carried out within two hours after the stress exposure (Trial 1) and repeated 2 hours thereafter (Trial 2). Intact males and females of the both mouse(More)
Repeated experience of aggression and submission in daily agonistic confrontations differently changed stress response in winners and losers of CBA/Lac and C57BL/6J strains. Experience of defeats was accompanied by expressed decrease of testosterone level in losers. Number of hemorrhages and erosions was significantly more in losers when compared to(More)
The effect of a mild cold stress on activity of the key enzyme of the serotonin biosynthesis: tryptophan hydroxylase (TPH) in the brain-stem and the pituitary-adrenal axis response were studied in male mice of 11 inbred strains. Considerable interstrain differences in the TPH activity and an increase of the plasma corticosteroids level were revealed in the(More)
During postnatal development the reaction of hypophysial-suprarenal system of young rats to subcutaneous injection of formaldehyde and immobilization appeared earlier (on the 4th day) than that to cooling and new environment (on the 12th day). Both in 16 days old and adult rats the increase of corticosteroid level in blood in response to different stress(More)
Studies have been made on the reaction of the hypophysial-adrenal system to the injection of adrenalin and novodrin to the ground squirrel C. erythrogenys at various seasons of year and at different functional conditions of the animals. Together with seasonal variations in the basal level of corticosteroids in the peripheral blood, seasonal changes in the(More)