L A Koriakina

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Chronic psychoemotional stress of social defeats produces development of experimental anxious depression in male mice similar to this disorder in humans. 5-HT and 5-HIAA levels, TPH and MAO A activities, 5-HT1A-receptors in different brain areas were investigated at different stages of development of experimental disorder. It has been shown that initial(More)
The role of genetic and seasonal factors in stress-induced changes of pain sensitivity, evaluated by latency in hot plate test was studied. Significant interstrain differences in restriction effect on pain sensitivity was established. Analgesia, hyperalgesia or lack of influence on pain sensitivity in mice of different strains was observed in response to(More)
Serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels, tryptophan hydroxylase (TPH) activity, and 5-HT1A receptor binding were studied in brain areas of male mice after repeated experience of victories (winners) and defeats (losers) in daily male confrontations. A decrease in the TPH activity in midbrain and its decrease in hypothalamus were shown(More)
The authors studied the effect of naltrexone (0.25 and 1.0 mg/kg, intraperitoneal injection) on the communicative and aggressive behavior of male C57BL/6J mice with experience in triumphs in 20 tests (victors) and of mice without such experience (novices). The level of communicativeness and aggression at the first confrontation was more marked in novices(More)
  • L A Koriakina
  • Rossiiskii fiziologicheskii zhurnal imeni I.M…
  • 1999
Mice-losers in social conflicts had an increased number of haemorrhages and erosions in gastric mucosa as compared with the control and winners-mice. Administration of ciproheptadine and/or ketanserin enhanced the neurogenic gastric damage both in the winners and in control mice. The CBA strain mice were more sensitive to the damaging effects of the drugs(More)
Three strains of inbred mice, C57BL/6J (C57), CBA/Lac (CBA), and BALB/c (BALB) were examined in the elevated plus-maze after the injection of an anxiotropic drug, a 5-HT1A agonist ipsapirone (3 mg/kg; i.p.; 30 min). Treatment with ipsapirone had different anxiogenic effects on the behavior of mice in accordance with their genotype. In C57 mice the drug(More)
The effect of a mild cold stress on activity of the key enzyme of the serotonin biosynthesis: tryptophan hydroxylase (TPH) in the brain-stem and the pituitary-adrenal axis response were studied in male mice of 11 inbred strains. Considerable interstrain differences in the TPH activity and an increase of the plasma corticosteroids level were revealed in the(More)
It has been shown that corticosteroid content of the blood in hibernating ground squirrels is the lowest. In spring, before the arousal, some increase in corticosteroid content is observed, although the latter remains lower than that in non-hibernating animals. During the arousal, corticosteroid content of the blood in the ground squirrels increased slowly(More)