L A Brostrom

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Evaluation of potential new treatment strategies requires adequate experimental tumor models which resemble the clinical situation as closely as possible. The purpose of the present study was to establish a new human osteosarcoma spontaneous metastasis model using orthotopic transplantation of histologically intact tumor tissue into the tibia of nude mice.(More)
Although basal circulating levels of individual islet cell hormones have been measured, few studies compared the molar ratios of the major hormones secreted by the endocrine pancreas. This study examined the basal levels of four major islet hormones: insulin, C-peptide (C-P), glucagon (G), and pancreatic polypeptide (PP) in normal subjects, in organ donors(More)
In order to evaluate and modify the radiosensitizing effect of carboplatin, amphotericin B (AmB) was given as pre-treatment to nude mice with bilateral subcutaneous human osteosarcoma xenografts. One of the two tumours in each animal was irradiated with a single dose of 12 Gy following treatment with AmB (5 mg kg(-1)), or carboplatin (20 mg kg(-1)), or AmB(More)
The effect of the two antineoplastic drugs, Adriamycin and methotrexate, on orthotopic bone, and on the induction of experimental heterotopic bone in rats was analyzed. The drugs were administered as single injections: Adriamycin in s.c. doses of 0.5 and 2 mg/kg body weight and methotrexate i.v. 100 and 250 mg/kg body weight followed by leucovorin rescue(More)
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