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An experimental model of subacute lead and benzene intoxication was induced in rabbits. It increased significantly delta-aminolevulinic acid (14C-ALA) incorporation into CNS myelin. ALA stably fixes on myelin proteins, especially Wolfgram proteins. In spite of this about one half of ALA incorporated into myelin linked with its basic proteins. Lead and… (More)
A-Aminolevulinic acid (ALA), the first metabolite in the system for synthesis of porphyrins and heme, and essential for the formation of cytochromes and other hemoproteins [i], is synthesized in cells of the CNS. Many toxic substances inhibit heme focmation at different stages after ALA formation, with the result that its synthesis is increased as a… (More)