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Newly identified apolipoprotein AV gene predisposes to high plasma triglycerides in familial combined hyperlipidemia.
Familial combined hyperlipidemia (FCHL) is the commonest form of hereditary hyperlipidemia (1) (2). Its primary defect is increased secretion of hepatic triglyceride (TG)-rich apolipoprotein B (apoExpand
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Serum paraoxonase activity: a new additional test for the improved evaluation of chronic liver damage.
BACKGROUND Paraoxonase 1 (PON1) is an ester hydrolase present in serum and in the liver. The aims of the present study were to investigate the following: (a) the relationship between serum PON1Expand
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Plasma homocysteine and the methylenetetrahydrofolate reductase C677T gene variant: lack of association with schizophrenia.
Disturbances in methyl-carbon metabolism, which result in hyperhomocysteinemia, have been associated with schizophrenia. Homozygosity for the T677 allele of the methylenetetrahydrofolate reductaseExpand
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Polymorphisms in human apolipoprotein(a) kringle IV-10 and coronary artery disease: relationship to allele size, plasma lipoprotein(a) concentration, and lysine binding site activity
Abstract Elevated plasma levels of lipoprotein(a) [Lp(a)] represent a major independent risk factor for the development of atherosclerosis. The kringle IV type 10 of apolipoprotein(a) [apo(a)] is theExpand
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Schizophrenic women with the APOE epsilon 4 allele have a worse prognosis than those without it.
The epsilon 4 allele of APOE is generally accepted to be a risk factor in Alzheimer's disease and it has been related to other neuropsychiatric disorders, including schizophrenia. The results ofExpand
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The variable phenotype in tetrasomy 18p syndrome. A propos of a subtle dysmorphic case.
The variable phenotype in tetrasomy 18p syndrome. Apropos of a subtle dysmorphic case: Tetrasomy 18 is a rare chromosomal syndrome. Its frequency is 1/40,000 newborns and more than 40 cases have beenExpand
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Molecular characterization of the fragile-X syndrome in the Mexican population.
The fragile X (fra-X) syndrome is the most frequent form of inherited mental retardation. Facial dysmorphism, macroorchidism and a folate-sensitive fragile site on Xq27.3 are commonly associatedExpand
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Linkage disequilibrium between IDUA kpnI-VNTR haplotype in Mexican patients with MPS-I.
BACKGROUND The MPS-I is an autosomal recessive disorder caused by mutations in the IDUA gene that induce to a deficiency of glycosidase alpha-L-iduronidase that is required for degradation of heparanExpand
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The MTHFR C677T, APOE, and PON55 gene polymorphisms show relevant interactions with cardiovascular risk factors.
Coronary artery disease (CAD) often cannot be explained by conventional risk factors (1). Various polymorphisms, such as MTHFR C677T, which causes hyperhomocysteinemia in the TT form (2), PON M55L,Expand
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