Léa M. M. Costes

Learn More
Interleukin-22 (IL-22) is a member of the IL-10 cytokine family that binds to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2. IL-22R expression was initially characterized on epithelial cells, and plays an essential role in a number of inflammatory diseases. Recently, a functional receptor was detected on cancer cells such as(More)
BACKGROUND The cholinergic anti-inflammatory pathway is proposed to be part of the so-called vago-vagal 'inflammatory reflex'. The aim of this study is to provide neuro-anatomical evidence to support the existence of a functional neuronal circuit and its activation in response to intestinal inflammation. METHODS The expression of c-fos was evaluated at(More)
Postoperative ileus is encountered by patients undergoing open abdominal surgery and is characterized by intestinal inflammation associated with impaired gastrointestinal motility. We recently showed that inflammation of the gut muscularis triggered activation of the vagal efferent pathway mainly targeting the inflamed zone. In the present study we(More)
BACKGROUND Postoperative ileus is characterized by a transient impairment of the gastrointestinal motility after abdominal surgery. The intestinal inflammation, triggered by handling of the intestine, is the main factor responsible for the prolonged dysmotility of the gastrointestinal tract. Secondary lymphoid organs of the intestine were identified as(More)
  • 1