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Recent imaging studies in healthy controls with a conditional stop signal reaction time (RT) task have implicated the subthalamic nucleus (STN) in response inhibition and the pre-supplementary motor area (pre-SMA) in conflict resolution. Parkinson's disease (PD) is characterized by striatal dopamine deficiency and overactivity of the STN and underactivation(More)
The aim of our study was to investigate two inter-related hypotheses about the role of the subthalamic nucleus. First that the subthalamic nucleus plays a role in adjusting response thresholds and speed-accuracy trade-offs and second that it is involved in reactive and proactive inhibition and conflict resolution. These were addressed by comparing the(More)
The present work focuses on the physiopathology of Parkinson's disease (PD), analyzing the alterations in neuro-transmitter profile of the basal ganglia triggered by the degeneration of cells from the substantia nigra compacta (SNpc). For this purpose, the neurochemical, morphological and molecular changes of the pedunculopontine nucleus (PPN) of rats upon(More)
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