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Early during de novo infection of human microvascular dermal endothelial (HMVEC-d) cells, Kaposi's sarcoma-associated herpesvirus (KSHV) (human herpesvirus 8 [HHV-8]) induces the host cell's preexisting FAK, Src, phosphatidylinositol 3-kinase (PI3-K), Rho-GTPases, Diaphanous-2 (Dia-2), Ezrin, protein kinase C-zeta, extracellular signal-regulated kinase 1/2(More)
ARCHON ™ (ARchitecture for Cooperative Heterogeneous ON-line systems) was Europe's largest ever project in the area of Distributed Artificial Intelligence (DAI). It devised a general-purpose architecture, software framework, and methodology which has been used to support the development of DAI systems in a number of real world industrial domains. Two of(More)
Computer-based systems are being used to tackle increasingly complex problems in ever more demanding domains. The size and amount of knowledge needed by such systems means they are becoming unwieldy and difficult to engineer into reliable, consistent products. One paradigm for overcoming this barrier is to decompose the problem into smaller more manageable(More)
Kaposi's sarcoma (KS), a vascular tumor associated with human immunodeficiency virus type 1 infection, is characterized by spindle-shaped endothelial cells, inflammatory cells, cytokines, growth and angiogenic factors, and angiogenesis. KS spindle cells are believed to be of the lymphatic endothelial cell (LEC) type. Kaposi's sarcoma-associated herpesvirus(More)
1 INTRODUCTION Artificial Intelligence (AI) techniques, and expert systems technology in particular, has often been used to tackle the most difficult automation problems. This is especially true in industrial applications where conventional software and teams of operators were unable to cope with the demands of rapidly changing, complex environments. After(More)
Multi-Agent Systems (MAS) in health-care domains are showing a rapid increase, in order to manage complex tasks and adapt gracefully to unexpected events. On the other hand, the lack of well-established agent-oriented engineering methodologies to transform knowledge level descriptions into deployable agent systems slackens MAS development. This paper(More)
A novel method for mapping a modifier gene that is syntenic to its major gene was used to map a male-sex-limited modifier of the expressivity of the Compact phenotype in the myostatin mutant (Mstn(Cmpt-dl1Abc)) Compact mouse. The modifier was mapped to the general region of D1Mit262, 40 cM distal to Mstn on chromosome 1. Myogenin, a postulated downstream(More)