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The cells in the hippocampal formation of rat, cat, rhesus monkey and human have been counted. The results show that there is a continuous increase both in granule and pyramidal cell numbers from rat to human. However, in human there is a disproportionate increase in the number of pyramidal cells of the regio superior. In the dentate gyrus the hilar region(More)
In this study the fine structure and synaptic connections of mossy cells in the rat and monkey fascia dentata were analyzed. In order to study commissural connections of identified mossy cells in the rat, hilar neurons were retrogradely labeled by horseradish peroxidase (HRP) or Fast Blue (FB) injections into the contralateral hippocampus. Vibratome(More)
One of the most distinctive and common cell types in Golgi preparations of the hilus of the rat dentate gyrus is the mossy cell. We have used a variety of techniques including the Golgi method, the combined Golgi and electron microscopic (EM) method and the retrograde transport of horseradish peroxidase (HRP) to study the development, ultrastructure and(More)
Recent studies have indicated that hippocampal GABAergic neurons in both the dentate gyrus and Ammon's horn contain immunoreactivity for the calcium-binding protein parvalbumin (PARV). Although the distribution of PARV-positive neurons has been previously described, detailed quantitative electron microscopic studies of the PARV-positive axon terminals in(More)
Cell proliferation has been studied in the human cerebellar cortex between the 24th gestational week and the 12th postnatal month. Intensive cell formation has been found in the external granular layer (EGL) of the human cerebellum, where the highest cell proliferation rate occurs between the 28th and 34th gestational weeks. This is followed by a gradual(More)
Mossy cells of the hippocampal dentate gyrus were analyzed through postnatal development. At birth, a few thorny excrescences were found on the proximal dendrites of mossy cells, whereas distal dendrites displayed pedunculate spines. Thorny excrescences increased in number and complexity until the third month. After that age, the complexity of thorny(More)
Five types of basket cell in the hippocampal denate gyrus of rats were analysed with a combined Golgi and electron microscopic method. Light microscopic observations show that the large somata of these different cell types are located either in the granule cell layer or within 30-50 micron of this layer. The somata of basket cells are pyramidal, horizontal,(More)
The rat dentate gyrus was examined with the Golgi method. Cell counts were performed in Nissl-stained serial sections. The number of granule cells was 635,000 +/- 33,000. The number of basket cells in the granular layer was 3600 +/- 570. In whole dentate gyrus, the average ratio between granule and basket cells was 160-220:1. The ratio was higher in the(More)
Calcium binding proteins calbindin D28k (CaBP) and parvalbumin (PV) are known to form distinct subpopulations of gamma-aminobutyric acid (GABA)ergic neurons in the rodent hippocampal formation. Light and electron microscopic morphology and connections of these protein-containing neurons are only partly known in the primate hippocampus. In this study, CaBP(More)
The postnatal generation, dendritic development and morphological variability of granule cells were studied in the monkey and human dentate gyrus. Granule cells are mainly formed prenatally in primates with an approximate 4- to 6-month postnatal generation time in humans. Dendritic development of individual granule cells appears to be prolonged over a long(More)