László Nagy

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We report here the identification of a novel cofactor, ACTR, that directly binds nuclear receptors and stimulates their transcriptional activities in a hormone-dependent fashion. ACTR also recruits two other nuclear factors, CBP and P/CAF, and thus plays a central role in creating a multisubunit coactivator complex. In addition, and unexpectedly, we show(More)
Macrophage uptake of oxidized low-density lipoprotein (oxLDL) is thought to play a central role in foam cell formation and the pathogenesis of atherosclerosis. We demonstrate here that oxLDL activates PPARgamma-dependent transcription through a novel signaling pathway involving scavenger receptor-mediated particle uptake. Moreover, we identify two of the(More)
The transcriptional corepressors SMRT and N-CoR function as silencing mediators for retinoid and thyroid hormone receptors. Here we show that SMRT and N-CoR directly interact with mSin3A, a corepressor for the Mad-Max heterodimer and a homolog of the yeast global-transcriptional repressor Sin3p. In addition, we demonstrate that the recently characterized(More)
sad et al., 1996), and CD32 (FcgRII; Stanton et al., 1992). The formation of foam cells from macrophages in the While the in vivo relevance of some of these proteins arterial wall is characterized by dramatic changes in remains to bedetermined, recent data support an imporlipid metabolism, including increased expression of tant role for both SR-A and CD36(More)
Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were thought to serve as simple energy storing molecules. More recently it has been realized that they can also initiate and regulate signaling events that will decisively influence development, cellular differentiation, metabolism and related functions through the(More)
The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) has important roles in adipogenesis and immune response as well as roles in both lipid and carbohydrate metabolism. Although synthetic agonists for PPARgamma are widely used as insulin sensitizers, the identity of the natural ligand(s) for PPARgamma is still not clear.(More)
Ecological conservation monitoring programmes abound at various organisational and spatial levels from species to ecosystem. Many of them suffer, however, from the lack of details of goal and hypothesis formulation, survey design, data quality and statistical power at the start. As a result, most programmes are likely to fail to reach the necessary standard(More)
phage gene expression. Although the mechanisms by which oxidized LDL (oxLDL) regulates cellular gene expression are still poorly understood, recent work suggests that transcriptional pathways involving nuclear receptors mediate many biological effects of oxidized by providing the cell with oxidized fatty acid ligands of University of Debrecen the receptor(More)
Nuclear receptors are central to the regulation of development, endocrine signalling and metabolism. The transcriptional activity of many receptors is controlled through the binding of small, fat-soluble molecules to the ligand-binding domain. In most cases, ligand binding turns the receptors into potent activators of transcription. This switch involves the(More)
Peroxisome proliferator-activated receptor γ (PPARγ) is a lipid-activated transcription factor regulating lipid metabolism and inflammatory response in macrophages and dendritic cells (DCs). These immune cells exposed to distinct inflammatory milieu show cell type specification as a result of altered gene expression. We demonstrate here a mechanism how(More)