Kyungsun Suh

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Histone deacetylase (HDAC) inhibitors are currently in human clinical trials as antitumor drugs because of their ability to induce cell dysfunction and death in cancer cells. The toxic effects of HDAC inhibitors are also apparent in cortical neurons in vitro, despite the ability of these agents to induce significant protection in the cells they do not kill.(More)
Oxidative stress contributes to tissue injury in conditions ranging from cardiovascular disease to stroke, spinal cord injury, neurodegeneration, and perhaps even aging. Yet the efficacy of antioxidants in human disease has been mixed at best. We need a better understanding of the mechanisms by which established antioxidants combat oxidative stress. Iron(More)
Brett Langley,1,2 Melissa A. D’Annibale,1 Kyungsun Suh,1,2 Issam Ayoub,3 Aaron Tolhurst,1 Birgül Bastan,4 Lichuan Yang,2 Brian Ko,1 Marc Fisher,4 Sunghee Cho,1,2 M. Flint Beal,2 and Rajiv R. Ratan1,2 1Burke Medical Research Institute, White Plains, New York 10605, 2Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New(More)
Cells infected with a temperature-sensitive mutant of vesicular stomatitis virus, ts045, or transfected with the plasmid vector pdTM12 produce mutant forms of the G protein that remain within the ER. The mutant G proteins were isolated by immunoprecipitation from cells metabolically labeled with [2-3H] mannose to facilitate analysis of the protein-linked(More)
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