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Molecular and functional evaluation of a novel HIF inhibitor, benzopyranyl 1,2,3-triazole compound
- Kyunghye Park, H. Lee, S. Lee, Doohyun Lee, Taeho Lee, Y. M. Lee
- Biology, ChemistryOncotarget
- 15 December 2016
Compound 12 can be a novel inhibitor of HIF-1α by accelerating its degradation, and shows much potential as an anti-cancer agent through its ability to suppress tumor growth and angiogenesis.
Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition
The SAR studies examined key regions of manassantin’s structure in order to understand the impact of these regions on biological activity and to define modifications that can lead to improved performance and drug-like properties, which provide an important framework to design potent and selective HIF-1α inhibitors.
Effects of DNA synthesis inhibitors on the induction of hCG subunits and alkaline phosphatase in HeLa S3 cells
- Kyunghye Park
Shed syndecan-2 enhances colon cancer progression by increasing cooperative angiogenesis in the tumor microenvironment.