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E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis
TLDR
It is shown that E2-EPF ubiquitin carrier protein (UCP) associates with and targets pVHL for ubiqu itin-mediated proteolysis in cells, thereby stabilizing HIF-1α and may be a new molecular target for therapeutic intervention in human cancers. Expand
Rgs13 Constrains Early B Cell Responses and Limits Germinal Center Sizes
TLDR
Results indicate that RGS13, likely acting at cell membranes and in nuclei, helps coordinate key decision points during the expansion and differentiation of naive B cells. Expand
Adenovirus-mediated interleukin-18 mutant in vivo gene transfer inhibits tumor growth through the induction of T cell immunity and activation of natural killer cell cytotoxicity
TLDR
The results suggest that the release of mature IL-18 in tumors is required for achieving an antitumor effect including tumor-specific cellular immunity and augmented NK cell-mediated cytotoxicity. Expand
Oncolytic effects of adenovirus mutant capable of replicating in hypoxic and normoxic regions of solid tumor.
TLDR
The results suggest that Ad.Delta55.HRE may be useful for the treatment of solid tumors and exhibited oncolytic effects on various cultured tumor cells, but its cytotoxic effect is relatively attenuated in normal fibroblast cells under normoxic and hypoxic conditions. Expand
Adenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts potent antitumor activity in Renca tumor-bearing mice
TLDR
The results suggest that adenovirus-mediated IL-12 gene transfer combined with Ad.CD followed by 5-FC treatment may be useful for treating cancers. Expand
Adeno‐associated virus‐mediated gene transfer of a secreted form of TRAIL inhibits tumor growth and occurrence in an experimental tumor model
TLDR
The biological activity of a novel, secreted form of TRAIL for cancer gene therapy using a rAAV2 vector is assessed using a Recombinant adeno‐associated virus (rAAV) vectors. Expand
951. Antitumor Activity of AAV-2 Vector Encoding Modified TRAIL Gene
TLDR
The results suggest that AAV-2/PLF-ITRAD may be useful for systemic cancer gene therapy, provided that TRAIL is not toxic to normal cells. Expand