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Triterpenoic acids of Prunella vulgaris var. lilacina and their cytotoxic activities In Vitro
The column chromatographic separation of the MeOH extract from the aerial parts of Prunella vulgaris var. lilacina Nakai led to the isolation of fifteen triterpenoic acids (2–6, 9–13, 16–20), four
Protoberberine alkaloids and their reversal activity of P-gp expressed multidrug resistance (MDR) from the rhizome ofCoptis japonica Makino
TLDR
Six protoberberine alkaloids were isolated from the chloroform layer of the rhizome ofCoptis japonica Makino (Ranunculaceae) and tested for cytotoxicity against five tumor cell lines in vitro by SRB method, and also tested for the MDR reversal activities.
Cytotoxic phenolic constituents ofAcer tegmentosum maxim
TLDR
The chromatographic separation of the MeOH extract from the twigs of Acer tegmentosum led to the isolation of ten phenolic compounds, which were examined for their cytotoxic activity against five cancer cell lines.
THREE NEW FLAVONOL GLYCOSIDES FROM THE AERIAL PARTS OF TETRAGONIA TETRAGONOIDES
Three new flavonol glycosides (1-3) and three known lignan amides (4-6) were isolated from the MeOH extract of the aerial parts of Tetragonia tetragonoides. The chemical structures of the new
Design and Synthesis of 5''-Iodoneplanocin A and Its Analogues as Potential S-Adenosylhomocysteine Hydrolase Inhibitor
5"-Iodoneplanocin A (1) and its analogues 2 and 3 were designed and synthesized as potential SAHH inhibitor via iodocyclopentenol 6, which was prepared using a Michael addition-iodination-elimination
A new indolinepeptide fromPaecilomyces sp. J300
A new indolinepeptide (3) was isolated, together with two known compounds, a cerebroside (1) and an alloxazine (2), from silkworm larvae infected withPaecilomyces sp. J300. On the basis of
New benzamide derivatives and NO production inhibitory compounds from Limonia acidissima.
TLDR
Three new benzamide derivatives, together with 10 known compounds, were isolated from the bark of Limonia acidissima and potently inhibited nitric oxide (NO) production in microglia cells.
Synthesis of novel apio carbocyclic nucleoside analogues as selective a(3) adenosine receptor agonists.
TLDR
This work has first developed novel carbocyclic nucleosides with unnatural apio-carbasugars using stereoselective hydroxymethylation and RCM reaction and discovered a new template of human A( 3) adenosine receptor agonist, which play a great role in developing new A(3)Adenosine receptors agonist as well as in identifying the binding site of the receptor.
A new acylglycosyl sterol from quisqualis fructus
TLDR
A new acylglycosyl sterol was isolated from the MeOH extract of Quisqualis Fructus together with four known compounds and their structures were elucidated as clerosterol, betulinic acid, methylursolate and α-xylofuranosyluracil.
Synthesis of 5'-substituted fluoro-neplanocin A analogues: importance of a hydrogen bonding donor at 5'-position for the inhibitory activity of S-adenosylhomocysteine hydrolase.
TLDR
Four 5'-substituted fluoro-neplanocin A analogues 1a-d were designed and synthesized, using cyclopentenone derivative 2 as a key intermediate, and showed much less decreased cytotoxicity in two cancer cell lines (Col2 and A549), implying that phosphorylation of the 5'-hydroxyl group of fluoro.
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