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Casticin, an active compound isolated from Vitex Fructus, ameliorates the cigarette smoke-induced acute lung inflammatory response in a murine model.
- Hyeonhoon Lee, Kyung-Hwa Jung, Hangyul Lee, Soojin Park, W. Choi, H. Bae
- International immunopharmacology
- 1 October 2015
It is indicated that casticin has significant effects on the lung inflammation induced by CS in a mouse model and may have therapeutic potential in inflammatory lung diseases, such as chronic obstructive pulmonary disease (COPD). Expand
The effects of the standardized herbal formula PM014 on pulmonary inflammation and airway responsiveness in a murine model of cockroach allergen-induced asthma.
The results indicate that PM014 has significant effects on allergic airway inflammation upon exposure to cockroach allergen in a mouse model, and may have therapeutic potential as a treatment for allergic asthma. Expand
Regulatory T Cells Contribute to the Inhibition of Radiation-Induced Acute Lung Inflammation via Bee Venom Phospholipase A2 in Mice
The results support the therapeutic potential of bvPLA2 in radiation pneumonitis and fibrosis treatments and demonstrate the attenuating effect of b vPLA2 on radiation-induced lung inflammation. Expand
Adenovirus-mediated Foxp3 expression in lung epithelial cells reduces airway inflammation in ovalbumin and cockroach-induced asthma model
- Soojin Park, H. Chung, +4 authors H. Bae
- Biology, Medicine
- Experimental & molecular medicine
- 1 September 2016
It is suggested that Foxp3 expression in lung epithelial cells, and not in Tregs, inhibited OVA- and cockroach extract-induced asthma. Expand
The Effects of Maekmoondong-Tang on Cockroach Extract-Induced Allergic Asthma
- Soojin Park, S. Sohn, +6 authors H. Bae
- Evidence-based complementary and alternative…
- 3 March 2014
It is demonstrated that MMDT significantly reduced the hallmark signs of asthma: elevated serum IgE, airway eosinophilia,Airway remodeling, mucus hypersecretion, and airway hyperresponsiveness. Expand
The inflammasome accelerates radiation-induced lung inflammation and fibrosis in mice.
- S. Sohn, Ji Min Lee, +7 authors H. Bae
- Biology, Medicine
- Environmental toxicology and pharmacology
- 1 March 2015
Upregulation of Cd68 and Tgfb1 correlates with the onset of radiation-induced pneumonitis and fibrosis, and is accompanied by upregulation of phenotypic markers of inflammasome activity. Expand
Tuberostemonine N, an active compound isolated from Stemona tuberosa, suppresses cigarette smoke-induced sub-acute lung inflammation in mice.
- Kyung-Hwa Jung, Yun‐Seo Kil, +5 authors H. Bae
- Phytomedicine : international journal of…
- 15 January 2016
Data suggest that tuberostemonine N exerts anti-inflammatory effects against airway inflammation, and T.N may be a novel therapeutic agent for lung diseases, such as COPD. Expand
Inhibitory effects of Stemona tuberosa on lung inflammation in a subacute cigarette smoke-induced mouse model
- Hyeonhoon Lee, Kyung-Hwa Jung, +5 authors H. Bae
- BMC Complementary and Alternative Medicine
- 20 December 2014
It is observed that the lung tissues of mice treated with ST showed ameliorated epithelial hyperplasia of the bronchioles compared with those of mice exposed only to CS, indicating that Stemona tuberosa may represent a novel therapeutic herb for the treatment of lung diseases including COPD. Expand
Bee venom phospholipase A2 suppresses allergic airway inflammation in an ovalbumin‐induced asthma model through the induction of regulatory T cells
- Soojin Park, Hyunjung Baek, +5 authors H. Bae
- Immunity, inflammation and disease
- 9 August 2015
It is demonstrated that bvPLA2 can mitigate airway inflammation by the induction of Tregs in an OVA‐induced asthma model and a significant reduction in the levels of Th2 cytokines and inflammatory cells in the BALF of b vPLA2‐treated OVA-induced mice is observed. Expand
The therapeutic effects of tuberostemonine against cigarette smoke-induced acute lung inflammation in mice.
- Kyung-Hwa Jung, Hyun-Jeong Beak, +5 authors H. Bae
- European journal of pharmacology
- 5 March 2016
The results suggest that TS has anti-inflammatory effects against CS-induced acute lung inflammation and significantly ameliorated the airway epithelial thickness induced by CS exposure and caused a significant decrement in the production of chemokines in the lung. Expand