Kyung Hoon Kim

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Poly(γ-4-((2-(piperidin-1-yl)ethyl)aminomethyl)benzyl-l-glutamate) (PPABLG), a cationic helical polypeptide, has been recently developed by us as an effective non-viral gene delivery vector. In attempts to elucidate the effect of molecular architecture on the gene delivery efficiencies and thereby identify a potential addition to PPABLG with improved(More)
Cell-penetrating peptides (CPPs) are routinely used for intracellular delivery of a variety of cargo, including drugs, genes, and short interfering RNA (siRNA). Most CPPs are active only upon exposure to acidic environments inside of late endosomes, thereby facilitating the endosomal escape of internalized vectors. Here, we describe the generation of a(More)
Intervention of the inflammation cascade with tumor necrosis factor-a (TNF-a) monoclonal antibodies or receptors represents a major approach in clinical immunotherapy against inflammatory diseases, which however, often suffers from high cost, autoimmunity to antibodies, and various side effects. [1] siRNA-mediated RNA interference (RNAi) has recently(More)
Nefopam (NFP) is a non-opioid, non-steroidal, centrally acting analgesic drug that is derivative of the non-sedative benzoxazocine, developed and known in 1960s as fenazocine. Although the mechanisms of analgesic action of NFP are not well understood, they are similar to those of triple neurotransmitter (serotonin, norepinephrine, and dopamine) reuptake(More)
In this work, we present the Genome Modeling System (GMS), an analysis information management system capable of executing automated genome analysis pipelines at a massive scale. The GMS framework provides detailed tracking of samples and data coupled with reliable and repeatable analysis pipelines. The GMS also serves as a platform for bioinformatics(More)
Nonviral gene delivery with synthetic cationic polymeric vectors is widely recognized as an attractive alternative to viral gene delivery, which suffers from inherent immunoge-nicity and various side effects. [1] The transfection efficiency and chemotoxicity of these polymeric vectors are often closely related to the density of their cationic charge. [2](More)
Poly(arginine) mimics bearing long hydrophobic side chains adopt stable helical conformation and exhibit helix-related cell-penetrating properties. Elongating polypeptide backbone length and increasing side chain hydrophobicity further increase the helicities of poly(arginine) mimics. They show superior cell membrane permeability up to two orders of(More)
PURPOSE To evaluate the structure-function relationships between retinal sensitivity measured by Humphrey visual field analyzer (HVFA) and the retinal nerve fiber layer (RNFL) thickness measured by scanning laser polarimetry (SLP) with variable corneal compensation (VCC) and enhanced corneal compensation (ECC) in glaucomatous and healthy eyes. METHODS(More)
BACKGROUND/AIMS Pegylated interferon (peginterferon) and ribavirin combination therapy is less effective and associated with a higher frequency of serious complications in chronic hepatitis C patients with cirrhosis than in noncirrhotic patients. This study evaluated the efficacy and tolerability of peginterferon and ribavirin treatment in patients with(More)