The 2nd order polynomial is commonly used for tting a response surface but the low order polynomial is not sufcient if the response surface is highly nonlinear. Based on genetic programming (GP), this paper presents a method with which high order smooth polynomials, which can model non-linear response surfaces, can be built. Since, in many cases small… (More)
BACKGROUND Patients with atopic dermatitis (AD) should be relatively well informed about the disorder to control their condition and prevent flare-ups. Thus far, there is no accurate information about the disease awareness levels and therapeutic behavior of AD patients. OBJECTIVE To collect data on patients' knowledge about AD and their behavior in… (More)
The point prevalence of atopic dermatitis (AD) among Korean adults visiting the Health Service Center for health check-ups was assessed. AD was diagnosed based on the questionnaires filled by patients and through physical examination by dermatologists. A total of 3,563 persons completed the questionnaires, and 2,032 persons were examined by the… (More)
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PURPOSE The purpose of this study was to investigate topographic characteristics of the retina in myopic eyes. METHODS We reviewed spectral-domain optical coherence tomography (SD-OCT) images of patients with myopia retrospectively. Retinal topography (RT) was defined as the topography of the retinal pigment epithelium layers. Retinal topographies were… (More)
BACKGROUND The pathogenesis of psoriasis may involve the interleukin (IL)-23 and Th17-mediated immune responses. Th17 cells secret IL-17 and IL-22, which mediates dermal inflammation and acanthosis. OBJECTIVE As inhibitor of nuclear factor κB kinase-α (IKKα) has been previously identified as a primary regulator of keratinocyte differentiation and… (More)
BACKGROUND Balneotherapy is widely used as an alternative treatment modality for AD. Although the clinical benefit of some mineral waters has been established, their mechanisms of action in alleviating AD are only partly understood. OBJECTIVE The clinical modification and immunomodulatory or anti-inflammatory effects of mineral water from the Suanbo hot… (More)
Drug delivery into neurological tissue is challenging because of the low tissue permeability. Ultrasound incorporating microbubbles has been applied to enhance drug delivery into these tissues, but the effects of a streaming flow by microbubble oscillation on drug perfusion have not been elucidated. In order to clarify the physical effects of steady… (More)