Kyu Suk Hwang

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UNLABELLED Nerve ligation injury may produce a pain syndrome that includes tactile allodynia. Reversal effects on tactile allodynia have been demonstrated after the intrathecal administration of gamma-aminobutyric acid (GABA) receptor agonists or cholinesterase inhibitors in rats. We examined the drug interactions between neostigmine and muscimol or(More)
BACKGROUND This study determined the effect of intrathecally administered cholinesterase inhibitors, edrophonium and neostigmine, on nerve injury-induced, touch-evoked allodynia and identified the pharmacologic characteristics of this action. METHODS Rats were prepared with tight ligation of the left L5 and L6 spinal nerves and with lumbar intrathecal(More)
Though the traditional flux balance analysis (FBA) has successfully predicted intracellular fluxes using stoichiometry, linear programming, and metabolic pathways, it has not automatically reflected any potential genetic effects in response to the environmental changes in the metabolic pathways. Recently, attempts have been made to impose regulatory(More)
UNLABELLED Intrathecal neostigmine reverses mechanical allodynia in humans and animals. The efficacy of morphine in a neuropathic pain state is still controversial. This study examines the antiallodynic interaction between morphine and neostigmine in a rat model of neuropathic pain. Rats were prepared with tight ligation of left L5-6 (fifth and sixth(More)
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