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Effects of donepezil, an acetylcholinesterase inhibitor, on neurogenesis in a rat model of vascular dementia
TLDR
Results indicated that donepezil improves cognitive function and enhances the survival of newborn neurons in the DG in the authors' animal model of VaD, possibly by enhancing the expression of choline acetyltransferase and brain-derived neurotropic factor. Expand
Neuroprotective effects of valproic acid against hemin toxicity: Possible involvement of the down-regulation of heme oxygenase-1 by regulating ubiquitin–proteasomal pathway
TLDR
The results indicate that VPA inhibits hemin toxicity by downregulating HO-1 protein expression, and provide a therapeutic strategy to attenuate intracerebral hemorrhagic injury. Expand
ATP induced microglial cell migration through non-transcriptional activation of matrix metalloproteinase-9
TLDR
The results from the present investigation may provide further insights into the regulation of the activity of MMP-9 during microglial migration, which may play essential role in theregulation of inflammatory responses in pathological situations such as neurodegenerative disorders. Expand
The Epigenetic Reader BRD2 as a Specific Modulator of PAI-1 Expression in Lipopolysaccharide-Stimulated Mouse Primary Astrocytes
TLDR
The data suggest that BRD2 is involved in the modulation of neuroinflammatory responses through PAI-1 and via the regulation of epigenetic reader BET protein, further providing a potential novel therapeutic strategy in neuroinflammatory diseases. Expand
Activation of Glucagon-Like Peptide-1 Receptor Promotes Neuroprotection in Experimental Autoimmune Encephalomyelitis by Reducing Neuroinflammatory Responses
TLDR
Exendin-4 administration to symptomatic EAE mice significantly improved the clinical signs of the disease, along with the reversal of histopathological sequelae such as cell accumulation, demyelination, astrogliosis, microglial activation, and morphological transformation of activated microglia in the injured spinal cord. Expand
The effects of IL-32 on the inflammatory activation of cultured rat primary astrocytes.
TLDR
The results from the present study suggest that IL-32 may play a role in the regulation of neuroinflammatory responses in several neurological disease conditions such as ischemia and Alzheimer's disease. Expand
Biphasic regulation of tissue plasminogen activator activity in ischemic rat brain and in cultured neural cells: Essential role of astrocyte-derived plasminogen activator inhibitor-1
TLDR
The results from the present study suggest that neurons are the major source of tPA and that the glutamate-induced stimulated release is mainly governed by neurons in the acute phase, while the massive up-regulation of PAI-1 in astrocytes during subchronic and chronic inflammatory conditions, leads to decreased tPA activity in the later stages of MCAO. Expand
Ginkgo biloba extract (Egb761) attenuates zinc-induced tau phosphorylation at Ser262 by regulating GSK3β activity in rat primary cortical neurons.
TLDR
Egb761 treatment attenuated the zinc-induced tau hyperphosphorylation at Ser262 in a concentration-dependent manner while the antioxidant N-acetylcysteine showed a similar effect and may be a candidate for the treatment of tauopathy present in neurological disorders such as Alzheimer's disease. Expand
Proteinase 3 Induces Neuronal Cell Death Through Microglial Activation
TLDR
The data presented here suggest that PR3 is a direct modulator of microglial activation and causes neuronal death through the augmentation of inflammatory responses and blocking PR3 would be a promising novel therapeutic target for neuroinflammatory disease such as stroke and Alzheimer's disease. Expand
Valproic Acid Regulates α-Synuclein Expression through JNK Pathway in Rat Primary Astrocytes
TLDR
VPA concentrationdependently increased the protein expression level of α-synuclein in cultured rat primary astrocytes with concomitant increase in mRNA expression level and the level of secreted α- synuclein was also increased by VPA. Expand
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