Kyu Jin Choi

Learn More
Bacterial resistance to antibiotics is a significant issue in both healthcare and community settings, causing increases in morbidity and mortality across the population. Bacterial resistance can be induced through random genetic mutations, the improper use of antibiotics, or the uptake of plasmid DNA from foreign cells. Any bacterium can evolve resistance.(More)
X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is well known as an antagonist of XIAP-mediated caspase inhibition. Although XAF1 serves as a tumor-suppressor gene, the role of XAF1 in cellular senescence remains unclear. We found that XAF1 expression was increased by genotoxic agents, such as doxorubicin and ionizing radiation in(More)
Since checkpoint kinase 1 (Chk1) is an essential factor for cell viability following DNA damage, the inhibition of Chk1 has been a major focus of pharmaceutical development to enhance the sensitivity of tumor cells to chemo- and radiotherapy that damage DNA. However, due to the off-target effects of conventional Chk1-targeting strategies and the toxicity of(More)
  • 1