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IL-10 is a multifunctional cytokine that plays a critical role in maintaining the balance between immunity and tolerance. Previously, we identified proximal regulatory elements and alterations of chromatin structure in the IL-10 gene loci of Th1 and Th2 cells. We have now characterized a crucial cis-regulatory element, CNS-9, located 9kb upstream of the(More)
Interleukin-10 (IL-10), an immunoregulatory cytokine, modulates the function of various immune and nonimmune cells, yet little information is available on the molecular mechanism of transcriptional regulation at the chromatin level. During T cell differentiation from naive T cells into Th1 and Th2 cells, the expression of IL-10 in Th1 cells slowly(More)
The immunoregulatory cytokine interleukin 10 (IL-10) modulates the function of diverse immune and non-immune cells. Here, we examine the chromatin structural changes associated with IL10 gene transcription by naive and differentiated murine T cells. Naive T cells lack DNase I hypersensitive (HS) sites in the vicinity of the IL10 gene, whereas differentiated(More)
BACKGROUND/AIMS We examined the effects according to the extent of surgical wound mimicking laparoscopy or laparotomy on ovarian cancer growth in an orthotopic mouse model. MATERIALS AND METHODS To mimic surgery effects, we performed laparoscopy or laparotomy on athymic nude mice under isoflurane inhalation at four days after tumor cell injection. For the(More)
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