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Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets.
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing β cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. ToExpand
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EBF2 determines and maintains brown adipocyte identity.
The master transcription factor Pparγ regulates the general differentiation program of both brown and white adipocytes. However, it has been unclear whether Pparγ also controls fat lineage-specificExpand
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Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation.
Histone acetylation plays important roles in gene regulation, DNA replication, and the response to DNA damage, and it is frequently deregulated in tumors. We postulated that tumor cell histoneExpand
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Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue
Significance Obesity has reached pandemic levels, prompting the need for novel therapeutics. The immune system has been suggested to be critically linked to metabolic health, leading to the prospectExpand
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Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.
Histone deacetylases (HDACs) are believed to regulate gene transcription by catalyzing deacetylation reactions. HDAC3 depletion in mouse liver upregulates lipogenic genes and results in severeExpand
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Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells.
Embryonic development is characterized by dynamic changes in gene expression, yet the role of chromatin remodeling in these cellular transitions remains elusive. To address this question, we profiledExpand
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Single-Cell Transcriptomics of the Human Endocrine Pancreas
Human pancreatic islets consist of multiple endocrine cell types. To facilitate the detection of rare cellular states and uncover population heterogeneity, we performed single-cell RNA sequencingExpand
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Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.
Prdm16 is a transcription factor that regulates the thermogenic gene program in brown and beige adipocytes. However, whether Prdm16 is required for the development or physiological function of brownExpand
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Ebf2 is a selective marker of brown and beige adipogenic precursor cells
Significance High levels of brown/beige fat activity protects animals against metabolic disease, but there has been little known about the precursor cells that mediate the expansion of brown or beigeExpand
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Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo.
Glucocorticoids (GCs) are commonly prescribed drugs, but their anti-inflammatory benefits are mitigated by metabolic side effects. Their transcriptional effects, including tissue-specific geneExpand
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