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Astrocytes Induce Hemeoxygenase-1 Expression in Microglia: A Feasible Mechanism for Preventing Excessive Brain Inflammation
TLDR
It is suggested that astrocytes could cooperate with microglia to prevent excessive inflammatory responses in the brain by regulating microglial expression of HO-1 and production of ROS.
Carnosic Acid Induces Apoptosis Through Reactive Oxygen Species-mediated Endoplasmic Reticulum Stress Induction in Human Renal Carcinoma Caki Cells
TLDR
Carnosic acid induced apoptosis through production of ROS and induction of ER stress in human renal carcinoma Caki cells and down-regulation of ATF4 and CHOP by small interfering RNA (siRNA) markedly reduced carnosic Acid-induced sub-G1 population and PARP cleavage.
Anti-inflammatory activity of hydroxycinnamic acid derivatives isolated from corn bran in lipopolysaccharide-stimulated Raw 264.7 macrophages.
TLDR
Results suggest that phenolic amides in the corn bran may be a potential source of natural anti-inflammatory agents.
Gangliosides activate microglia via protein kinase C and NADPH oxidase
TLDR
The results collectively suggest that gangliosides activate microglia via PKC and NADPH oxidase, which regulate activation of NF‐κB.
Plasminogen-induced IL-1β and TNF-α production in microglia is regulated by reactive oxygen species
TLDR
It is shown that the blood component plasminogen/plasmin activates microglia via stimulation of ROS production, and this activation was also reduced by trolox and NAC.
Phospholipase D Isozymes Mediate Epigallocatechin Gallate-induced Cyclooxygenase-2 Expression in Astrocyte Cells*
TLDR
It is demonstrated for the first time that PLD isozymes mediate EGCG-induced COX-2 expression through PKC and p38 in immortalized astroglial line and normal astrocyte cells.
Curcumin inhibits oxLDL-induced CD36 expression and foam cell formation through the inhibition of p38 MAPK phosphorylation.
TLDR
Results suggest that curcumin modulates oxLDL-induced CD36 expression and foam cell formation via the inhibition of p38 MAPK phosphorylation in RAW 264.7 murine macrophages.
Glucocorticoid receptor antagonist sensitizes TRAIL-induced apoptosis in renal carcinoma cells through up-regulation of DR5 and down-regulation of c-FLIP(L) and Bcl-2
TLDR
Taken together, RU486 enhances TRAIL-mediated apoptosis through down-regulation of Bcl-2 and c-FLIP(L) as well as CHOP-mediated DR5 up-regulation, which contributes to RU-486 induced TRAIL sensitization.
Anti-inflammatory roles of retinoic acid in rat brain astrocytes: Suppression of interferon-gamma-induced JAK/STAT phosphorylation.
TLDR
RA induces an anti-inflammatory effect by suppressing the activation of the JAK/STAT pathway in IFN-gamma-treated astrocytes, and suppressors of cytokine signaling (SOCS) may be candidate mediators of the anti- inflammatory function of RA.
β-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells
TLDR
The results demonstrate that β-lapachone induces programmed necrosis through the NQO1-dependent ROS-mediated RIP1-PARP1-AIF pathway.
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