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The Draft Genome of Ciona intestinalis: Insights into Chordate and Vertebrate Origins
The first chordates appear in the fossil record at the time of the Cambrian explosion, nearly 550 million years ago. The modern ascidian tadpole represents a plausible approximation to these… Expand
Gene expression profiles of transcription factors and signaling molecules in the ascidian embryo: towards a comprehensive understanding of gene networks
Achieving a real understanding of animal development obviously requires a comprehensive rather than partial identification of the genes working in each developmental process. Recent decoding of… Expand
Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.
- Kyosuke Hino, M. Ikeya, +8 authors J. Toguchida
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 15 December 2015
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by extraskeletal bone formation through endochondral ossification. FOP patients harbor point mutations in ACVR1… Expand
A genomewide survey of developmentally relevant genes in Ciona intestinalis
Cell–cell interactions play important roles in a variety of developmental processes, and therefore molecules involved in the signaling pathways have been studied extensively. Recently, the draft… Expand
Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva.
- Kyosuke Hino, K. Horigome, +9 authors M. Ikeya
- The Journal of clinical investigation
- 31 July 2017
Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disease characterized by extraskeletal bone formation through endochondral ossification. Patients with FOP harbor point mutations… Expand
New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans Progressiva.
Successful in vitro disease-recapitulation using patient-specific induced pluripotent stem cells (iPSCs) requires two fundamental technical issues: appropriate control cells and robust… Expand
High-Throughput Screening for Small-Molecule Adiponectin Secretion Modulators
- Kyosuke Hino, Hidetaka Nagata, M. Shimonishi, Motoharu Ido
- Biology, Medicine
- Journal of biomolecular screening
- 1 July 2011
Adiponectin is an adipokine secreted by adipocytes and plays a role in the suppression of metabolic disorders that can result in type 2 diabetes, obesity, and atherosclerosis. Several studies have… Expand
An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva
Summary Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disorder characterized by extraskeletal bone formation through endochondral ossification. FOP patients harbor… Expand
Paramvir Dehal Vertebrate Origins : Insights into Chordate and Ciona intestinalis The Draft Genome
, 2157 (2002); 298 Science et al. Paramvir Dehal Vertebrate Origins : Insights into Chordate and Ciona intestinalis The Draft Genome of This copy is for your personal, non-commercial use only.… Expand
[Application of disease-specific iPS cells for intractable diseases-from pathomechanisms to drug discovery].
Genetic diseases affecting bone and cartilage, which are main components of the locomotive system, are extremely diverse. Even if the causative genes are known, detail pathomechanisms are not yet… Expand