Kyoko Uekusa

Learn More
BACKGROUND The four-vessel occlusion method introduced by Pulsinelli et al. is widely used as an experimental model for reversible forebrain ischemia in rats. METHOD In this study, we further developed highly reproducible model of reversible forebrain ischemia. Under the microscope the visible vertebral arteries at the second vertebra could be easily(More)
An accidental case of aconite intoxication occurred after a patient took a therapeutic dose of Kampo herbal medicine containing Aconiti tuber, Uzu but had used the wrong decoction procedure. The poisoning was likely caused by an increased level of Aconitum alkaloids in the decoction; the patient developed aconite intoxication due to incomplete decoction.(More)
There are few reports from Japan on the analysis of fluids in survivors of body-packer syndrome. We analyzed the concentrations of stimulants in the serum, plasma and urine collected from three patients suspected of being body packers at immigration that were referred to hospitals between 2010 and 2011. The drugs were extracted with solid-phase columns and(More)
We analyzed whether gel bleed, the leakage of silicone gel from breast implants, occurs in the human body. We simulated the phenomenon with olive oil. Silicone breast implants were submerged in olive oil, and the concentration of silicone polymers in the olive oil was measured periodically with nuclear magnetic resonance spectroscopy. We found no increase(More)
Magnetic resonance imaging and spectroscopy (MRI and MRS) were used to examine the effects of intoxicating doses of ethanol on the rat brain. 1H-MR images were obtained using three different methods: (1) PD weighted images, (2) T1 weighted images and (3) T2 weighted images. T1 and T2 relaxation times of the tissues were calculated by pixel-to-pixel image(More)
Forensic toxicological drug analyses of human specimens are usually performed immediately after autopsy or on frozen preserved tissues. Occasionally, cases require analysis of drugs from tissues fixed in formalin solution. To improve the estimation of the level of drug in tissues following formalin fixation, we studied drug concentrations in human tissues,(More)
A 44-year-old woman was admitted to our hospital for further evaluation of a consolidated shadow in the left lower lobe and the evaluation of serum tumor markers (CEA 46.3 ng/ml, CA 19-9 1911 U/ml, and CA 125 103 U/ml). Chest computed tomography revealed an irregular shaped, low density mass shadow in the left S10 region, suggesting the diagnosis of(More)
An unconscious 20-year-old female was admitted to hospital with a heart rate of 164, a blood pressure of 132/90 mmHg, and hypokalemia. "Triage" urine screening tests were negative on arrival and 12 h later. The next day, her SGOT and SGPT levels rose remarkably; however, on the third day, the patient regained consciousness. Two Japanese OTC drugs and an(More)
Flumazenil was studied on cocaine intoxicated rats for its preventive effect on seizure, death and loss of righting reflex. Two minutes after the intraperitoneal injection of cocaine (70 mg/kg) into a rat, flumazenil and diazepam were administered at the clinically corresponding dose intraperitoneally. Flumazenil at a dose 0.125 mg/kg extended the onset(More)
Nuclear magnetic resonance (NMR) spectroscopy has recently been applied to metabolic studies. In particular, metabolic profiles of tissues or of the whole body can easily be acquired through multivariate analysis of NMR spectra. The present study investigates metabolic changes after death in rat femoral muscles using pattern recognition of proton NMR(More)
  • 1