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miR-4728-3p Functions as a Tumor Suppressor in Ulcerative Colitis-associated Colorectal Neoplasia Through Regulation of Focal Adhesion Signaling
Background: As mechanisms of neoplasia in patients with ulcerative colitis (UC) remain poorly understood, we sought to identify pathways of carcinogenesis in this high-risk population. Methods:Expand
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Oligonucleotides and G-quadruplex stabilizers: targeting telomeres and telomerase in cancer therapy.
Cancer is a leading cause of death worldwide and an estimated 1 in 4 deaths in the United States is due to cancer. Despite recent advances in cancer treatment, adverse effects related to cancerExpand
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EGFR and c-Met Inhibitors are Effective in Reducing Tumorigenicity in Cancer
EGFR and c-Met are receptor tyrosine kinases that are implicated in tumor development and progression in several types of cancer. Both EGFR and c-Met, which are known to be overexpressed and mutatedExpand
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c-Met: A Potential Target for Current Non-Small-Cell Lung Cancer Therapeutics
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. In early stages of NSCLC tumor development (stage I/II), surgical resection is often performed; however, when the cancerExpand
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Abstract 1838: Mechanism of EGFR and c-Met TKI resistance and role of co-expression of EGFR and c-Met in non-small cell lung cancer patients
Current EGFR/c-Met tyrosine kinase inhibitor (TKI) combination therapies are shown to be susceptible to acquired resistance in the majority of NSCLC patients. To understand how cells developExpand
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Abstract 743: Expression profiles of EGFR, c-Met, and mTOR/Wnt alternative signaling pathway proteins in non-small cell lung cancer
Lung cancer is projected to be the number one cause of cancer mortality in the United States in 2014. Therapies such as tyrosine kinase inhibitors (TKIs) have been developed to treat non-small cellExpand
940 miRNA and mRNA Profiles From Nondysplastic Mucosa Distinguish UC Patients Harboring Remote Neoplasia and Uncover MiR-4728-3p, a Predicted Regulator of Focal Adhesion, As a Tumor Suppressor in UC
Introduction: In prior studies, we identified RNAs in non-dysplastic mucosa that distinguished patients with ulcerative colitis (UC) and concomitant neoplastic lesions from those without neoplasia.Expand
An audit of the use of parenteral nutrition at Royal Bolton Hospital
people in Nigeria have been using natural plant products in this regard; efforts are on to carry out proper scientific investigations to determine the mechanism of action and bioactive compounds inExpand