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A well-preserved Cambrian section in the Zanskar Valley of northern India has previously been interpreted to record the transition from a passive to an active tectonic margin related to Cambrian–Ordovician orogenesis. This interpretation has been used to support the tectonostratigraphic interpretation of other successions across the Tethyan Himalaya. Our(More)
OBJECTIVES To examine mortality and revision rates among patients with osteoarthritis undergoing hip arthroplasty and to compare these rates between patients undergoing cemented or uncemented procedures and to compare outcomes between men undergoing stemmed total hip replacements and Birmingham hip resurfacing. DESIGN Cohort study. SETTING National(More)
Access to big datasets from e-health records and individual participant data (IPD) meta-analysis is signalling a new advent of external validation studies for clinical prediction models. In this article, the authors illustrate novel opportunities for external validation in big, combined datasets, while drawing attention to methodological challenges and(More)
Aims Prognostic models are statistical models that predict the risk of a future clinical outcome for individuals, and they are increasingly being developed using existing data from clinical trials. In this presentation we consider the challenges of this approach. Methods Using data from two clinical trials in advanced stage pancreatic cancer, a prognostic(More)
Additional material is published online only. To view please visit the journal online. Validation of prediction models is highly recommended and increasingly common in the literature. A systematic review of validation studies is therefore helpful, with meta-analysis needed to summarise the predictive performance of the model being validated across different(More)
INTRODUCTION Ovarian cancer (OC) is associated with non-specific symptoms such as bloating, making accurate diagnosis challenging: only 1 in 3 women with OC presents through primary care referral. National Institute for Health and Care Excellence guidelines recommends sequential testing with CA125 and routine ultrasound in primary care. However, these(More)
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