Kylie D. Allen

Publications16
h-index8
Citations206
Highly Influential Citations10
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A Pterin-Dependent Signaling Pathway Regulates a Dual-Function Diguanylate Cyclase-Phosphodiesterase Controlling Surface Attachment in Agrobacterium tumefaciens
TLDR
This study provides the first prokaryotic example of a pterin-mediated signaling pathway and a new model for the regulation of dual-function DGC-PDE proteins in the model pathogen Agrobacterium tumefaciens. Expand
Identification of structurally diverse methanofuran coenzymes in methanococcales that are both N-formylated and N-acetylated.
TLDR
This work uses liquid chromatography coupled with high-resolution mass spectrometry and a variety of biochemical methods to deduce the unique structures of MFs present in four different methanogen in the order Methanococcales, the first detailed characterization of the MF occurring in methanogens of this order. Expand
Discovery of Multiple Modified F430 Coenzymes in Methanogens and Anaerobic Methanotrophic Archaea Suggests Possible New Roles for F430 in Nature
TLDR
Liquid chromatography–high-resolution mass spectrometry is used to identify several new structural variants of F430 in the cell extracts of selected methanogens and ANME, indicating that F430-related molecules have additional functions in nature and will inspire further research to determine the biochemical role(s) of these variants and the pathways involved in their biosynthesis. Expand
In vitro phosphinate methylation by PhpK from Kitasatospora phosalacinea.
TLDR
The activity of the P-methyltransferase enzyme, PhpK, is demonstrated from the phosalacine producer Kitasatosporaphosalacinea to give rise to the only carbon-phosphorus-carbon linkage known to occur in nature. Expand
Initial characterization of Fom3 from Streptomyces wedmorensis: The methyltransferase in fosfomycin biosynthesis.
TLDR
Spectroscopic analyses demonstrate that Fom3 binds a [4Fe-4S] cluster which undergoes a transition between a +2 "resting" state and a +1 active state characteristic of radical SAM enzymes, and site-directed mutagenesis of the cysteine residues in the radical SAM CxxxCxxC motif indicates that each residue is essential for functional cluster formation. Expand
Identification of a unique radical S-adenosylmethionine methylase likely involved in methanopterin biosynthesis in Methanocaldococcus jannaschii.
TLDR
It is proposed that this archaeal radical SAM methylase employs a previously uncharacterized mechanism for methylation, using methylenetetrahydrofolate as a methyl group donor. Expand
Spectroscopic characterization and mechanistic investigation of P-methyl transfer by a radical SAM enzyme from the marine bacterium Shewanella denitrificans OS217.
TLDR
The results suggest that SD_1168 catalyzes P-methylation using radical SAM-dependent chemistry with cobalamin as a coenzyme suggests that S. denitrificans produces a phosphinate natural product. Expand
Homocysteine is biosynthesized from aspartate semialdehyde and hydrogen sulfide in methanogenic archaea.
TLDR
It is demonstrated that Methanocaldococcus jannaschii can biosynthesize homocysteine from aspartate semialdehyde and hydrogen sulfide and confirmed the genes involved in this new pathway in Methanosarcina acetivorans. Expand
Investigation of enzymatic C–P bond formation using multiple quantum HCP nuclear magnetic resonance spectroscopy
TLDR
A combination of stable isotopes and two‐dimensional nuclear magnetic resonance spectroscopy is utilized to obtain further insight into the catalytic mechanism of PhpK, the P‐methyltransferase responsible for the formation of the second C–P bond in l‐phosphinothricin. Expand
Occurrence and biosynthesis of 3-mercaptopropionic acid in Methanocaldococcus jannaschii.
TLDR
It is shown that HMBA can be biosynthesized from malate semialdehyde and hydrogen sulfide, likely using a mechanism similar to that proposed for coenzyme M, coen enzyme B and homocysteine biosynthesis in methanogens, where an aldehyde is converted to a thiol. Expand
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