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Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor.
TLDR
It is demonstrated that KSC-34 has minimal sustained effects on the cellular unfolded protein response, indicating that a-site inhibition does not induce global protein folding-associated ER stress, and useful tools for delineating the pathological role and therapeutic potential of PDIA1.
Ultra-stable hemoglobin–poly(acrylic acid) conjugates
Stabilization of proteins against thermal deactivation is a major challenge, and a simple, facile, novel chemical approach is described here to overcome this hurdle. We report here, for the first
Toward "stable-on-the-table" enzymes: improving key properties of catalase by covalent conjugation with poly(acrylic acid).
TLDR
This simple, facile, and rational methodology produced thermostable, storable catalase that is also protected from protease digestion and ascorbate inhibition and most likely prevented the dissociation of the multimer.
Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor
TLDR
CWR-J02 is identified as an intracellularly effective Grx1 inhibitor that may elicit its anti-inflammatory action in a synergistic manner by also disabling other pro-inflammatory mediators.
Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKα.
TLDR
Not only was JRA-003 identified as the most potent synthetic gibberellin against cancer-derived cell lines, it displayed no cytotoxicity in cells derived from noncancerous sources and suggests a promising approach for the development of new therapeutics.
Triazine Probes Target Ascorbate Peroxidases in Plants1
TLDR
It is shown that small 1,3,5-triazines selectively target ascorbate peroxidases (APXs) in Arabidopsis, tomato, rice, maize, liverwort, and other plant species, suggesting that APX enzymes in addition to APX1 protect the photosystem against reactive oxygen species.
Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKalpha
The small molecule gibberellin JRA-003 (1) was identified as an inhibitor of the NF-kB (nuclear kappa-light-chain enhancer of activated B cells) pathway. Here we find that JRA-003 binds to and
Triazine Probes Target Ascorbate Peroxidases in Plants.
TLDR
It is shown that small 1,3,5-triazines selectively target ascorbate peroxidases (APXs) in Arabidopsis, tomato, rice, maize, liverwort, and other plant species, suggesting that APX enzymes in addition to APX1 protect the photosystem against reactive oxygen species.
Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKalpha
The small molecule gibberellin JRA-003 (1) was identified as an inhibitor of the NF-kB (nuclear kappa-light-chain enhancer of activated B cells) pathway. Here we find that JRA-003 binds to and
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